- Technical notes
- Beta cells for disease modeling
- Efficient generation of hiPSC-derived disease model for primary hyperoxaluria type 1
- Edited hiPS cell lines for disease modeling
- Power medium for intrinsic clearance studies
- Exploring the potential of a hiPSC-derived hepatocyte disease model for NASH using bioinformatics
- Selection guides
Efficient generation of hiPSC-derived disease model for primary hyperoxaluria type 1
Human induced pluripotent stem cell (hiPSC) technology has led to major breakthroughs in the fields of human biology and engineering. Human iPSCs are now widely used for many applications, including developmental biology studies, disease modeling, drug screening, and regenerative medicine. However, their cultivation, expansion, and differentiation towards desired cell populations for disease modeling remain challenging.
In this webinar, Dr. Julie Estève describes the efficient generation of a hiPSC-derived hepatocyte model for primary hyperoxaluria type 1 (PH1), a rare inborn hepatic disease that is often caused by a mutation in the alanine-glyoxylate and serine-pyruvate aminotransferase (AGXT) gene.
- Pathophysiology of PH1 and current therapeutic strategies
- Generation of hiPSCs from PH1 patient-derived fibroblasts
- Monolayer culture and expansion of PH1-hiPSCs under feeder-free conditions
- Efficient differentiation of PH1-hiPSCs to hepatocytes
- Demonstration of the therapeutic benefit of AGXT gene therapy in PH1-HLCs
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