Optimized column design offers unique advantages
The innovative internal funnel design (Figure 1) allows standard miniprep spin columns to hold a silica membrane of very small diameter. The small diameter of the NucleoSpin cfDNA XS membrane allows efficient elution in only 5–20 μl, resulting in highly concentrated DNA that is ready for all typical downstream applications. The ability to purify highly concentrated circulating DNA allows for increased sensitivity and better results.
Elution volume depends on membrane diameter
The Xtra Small diameter of the NucleoSpin cfDNA XS column membrane (Figure 2) allows efficient elution in only 5–20 μl, compared to at least 20–30 µl using the Competitor Q kit designed for very small samples.