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COVID-19 research

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COVID-19 publications

Our customers and collaborators continue to make inroads in our understanding of SARS-CoV-2 using a broad range of scientific techniques. Cited below are selected studies in which our products and technologies were utilized to advance this research.

Publications grouped by application

Cloning

Title Link Product
Cloning
Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses In-Fusion technology
Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections In-Fusion HD Cloning Kit
Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza In-Fusion technology, Stellar chemically competent cells
Stability of RNA sequences derived from the coronavirus genome in human cells In-Fusion HD technology
Cloning of ACE2 isoforms
The heterogeneous nature of the Coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia In-Fusion SMARTer Directional cDNA Library Construction kit

Lentiviral titration

Title Link Product
Lentiviral titration (pseudovirus assay)
A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry Lenti-X GoStix Plus
Nanoluciferase complementation-based biosensor reveals the importance of N-linked glycosylation of SARS-CoV-2 Spike for viral entry Lenti-X GoStix Plus
Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells Lenti-X p24 Rapid Titer Kit

Protein purification

Title Link Product
Protein purification
A rapid, point of care red blood cell agglutination assay for detecting antibodies against SARS-CoV-2 Capturem His-Tagged Purification Miniprep Kit
Dynamics of neutralizing antibody titers in the months after SARS-CoV-2 infection TALON resin
Functional SARS-CoV-2-specific immune memory persists after mild COVID-19 TALON resin
Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans TALON resin
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects TALON resin
Structural characterisation of a nanobody derived from a naïve library that neutralises SARS-CoV-2 TALON resin
Ultra-sensitive high-resolution profiling of anti-SARS-CoV-2 antibodies for detecting early seroconversion in COVID-19 patients TALON resin

RNA-seq

Title Link Product
Single-cell RNA-seq
A method to identify respiratory virus infections in clinical samples using next-generation sequencing SMARTer Stranded RNA-Seq Kit
Defining the pandemic at the state level: sequence-based epidemiology of the SARS-CoV-2 virus by the Arizona COVID-19 Genomics Union (ACGU) SMART-Seq Stranded Kit
Stranded RNA-seq
Complete genome sequence of a SARS-CoV-2 strain isolated in northern Germany SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian
European context of the diversity and phylogenetic position of SARS-CoV-2 sequences from Polish COVID-19 patients SMART-Seq Stranded Kit
Genomic epidemiology of SARS-CoV-2 in Guangdong Province, China SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian
Genomics functional analysis and drug screening of SARS-CoV-2 SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian
SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian
Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian
Ultra-low input RNA-seq
Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2 SMART-Seq v4 Ultra Low Input RNA Kit
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques SMART-Seq v4 Ultra Low Input RNA Kit
Coronavirus disease (COVID-19) and fertility: viral host entry protein expression in male and female reproductive tissues SMART-Seq v4 Ultra Low Input RNA Kit
Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders SMART-Seq v4 Ultra Low Input RNA Kit
Functional SARS-CoV-2-specific immune memory persists after mild COVID‑19 SMART-Seq v4 Ultra Low Input RNA Kit
Human iPSC-derived cardiomyocytes are susceptible to SARS-CoV-2 infection SMART-Seq v4 Ultra Low Input RNA Kit
SARS-CoV-2 infection and replication in human fetal and pediatric gastric organoids SMART-Seq v4 Ultra Low Input RNA Kit

RT-qPCR

Title Link Product
One-step RT-qPCR applications
A novel coronavirus from patients with pneumonia in China, 2019 One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Stability of RNA sequences derived from the coronavirus genome in human cells PrimeScript RT Master Mix (Perfect Real Time)
A new coronavirus associated with human respiratory disease in China One Step PrimeScript RT-PCR Kit (Perfect Real Time)
A novel protein drug, Novaferon, as the potential antiviral drug for COVID-19 One Step PrimeScript RT-PCR Kit (Perfect Real Time)
A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection One Step PrimeScript III RT-PCR Kit
A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection One Step PrimeScript RT-PCR Kit (Perfect Real Time)
In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Comparison of SARS-CoV2 N gene real-time RT-PCR targets and commercially available mastermixes One Step PrimeScript III RT-PCR Kit
Detection of SARS-CoV-2 in pets living with COVID-19 owners diagnosed during the COVID-19 lockdown in Spain: A case of an asymptomatic cat with SARS-CoV-2 in Europe One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Heat inactivating and reusing of virus-contaminated disposable medical mask One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Search for SARS-CoV-2 inhibitors in currently approved drugs to tackle COVID-19 pandemia PrimeScript RT Reagent Kit (Perfect Real Time)
Brief comparative evaluation of six open one-step RT-qPCR mastermixes for the detection of SARS-CoV-2 RNA using a Taqman probe One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Extraction-free SARS-CoV-2 detection by rapid RT-qPCR universal for all primary respiratory materials PrimeDirect Probe RT-qPCR Mix
A thermostable mRNA vaccine against COVID-19 One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination One Step PrimeScript III RT-PCR Kit
Characteristics and early prognosis of COVID-19 infection in fracture patients One Step PrimeScript RT-PCR Kit (Perfect Real Time)
GRL-0920, an indole chloropyridinyl ester, completely blocks SARS-CoV-2 infection One Step PrimeScript III RT-PCR Kit
Community evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission through air PrimeScript One Step RT-PCR Kit Ver.2
Comparison of saliva and nasopharyngeal swab SARS-CoV-2 RT-qPCR testing in a community setting One Step PrimeScript III RT-PCR Kit
SARS-CoV-2 is restricted by zinc finger antiviral protein despite preadaptation to the low-CpG environment in humans PrimeScript RT Reagent Kit (Perfect Real Time)
Detection of SARS-CoV-2 in wastewater in Japan during a COVID-19 outbreak One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells One Step PrimeScript III RT-PCR Kit
Identifying the risk of SARS-CoV-2 infection and environmental monitoring in airborne infectious isolation rooms (AIIRs) One Step PrimeScript RT-PCR Kit (Perfect Real Time)
A SARS-CoV-2 variant with the 12-bp deletion at E gene One Step PrimeScript RT-PCR Kit (Perfect Real Time)
RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Development and evaluation of a rapid and simple diagnostic assay for COVID-19 based on loop-mediated isothermal amplification One Step PrimeScript III RT-PCR Kit
SARS-CoV-2 clearance in COVID-19 patients with Novaferon treatment: A randomized, open-label, parallel-group trial One Step PrimeScript RT-PCR Kit (Perfect Real Time)
An open-label, randomized trial of the combination of IFN-κ plus TFF2 with standard care in the treatment of patients with moderate COVID-19 One Step PrimeScript RT-PCR Kit (Perfect Real Time)
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Recovering coronavirus from large volumes of water
 

One Step PrimeScript RT-PCR Kit (Perfect Real Time)

One Step PrimeScript III RT-PCR Kit

Contamination-free visual detection of SARS-CoV-2 with CRISPR/Cas12a: A promising method in the point-of-care detection One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease One Step PrimeScript RT-PCR Kit (Perfect Real Time)
A mouse model of SARS-CoV-2 infection and pathogenesis
 
One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Antibody-like proteins that capture and neutralize SARS-CoV-2

One Step PrimeScript III RT-PCR Kit

PrimeDirect Probe RT-qPCR Mix

Role of neutrophil chemoattractant CXCL5 in SARS-CoV-2 infection-induced lung inflammatory innate immune response in an in vivo hACE2 transfection mouse model One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Newly identified viral genomes in pangolins with fatal disease One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Pathogenicity of porcine deltacoronavirus (PDCoV) strain NH and immunization of pregnant sows with an inactivated PDCoV vaccine protects 5‐day‐old neonatal piglets from virulent challenge One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection One Step PrimeScript RT-PCR Kit (Perfect Real Time)
Beta- and novel delta-coronaviruses are identified from wild animals in the Qinghai-Tibetan Plateau, China PrimeScript One Step RT-PCR Kit Ver.2
Interleukin-1β modulation of the mechanobiology of primary human pulmonary fibroblasts: potential implications in lung repair

One Step PrimeScript RT-PCR Kit (Perfect Real Time)

One-Step TB Green PrimeScript RT-PCR Kit II (Perfect Real Time)

SMARTScribe applications
ApharSeq: an extraction-free early-pooling protocol for massively multiplexed SARS-CoV-2 detection SMARTScribe Reverse Transcriptase
Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients SMARTScribe Reverse Transcriptase
cDNA panels
A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infection Human Cell Line MTC Panel

Find more products for COVID-19 research

  • Viral RNA isolation
  • Processing respiratory samples
  • Processing water samples
  • Viral detection via qPCR
  • Direct viral detection via qPCR
  • Viral and host sequencing
  • Immune profiling
  • Vaccine development
  • CRISPR screening

Helping researchers tackle COVID-19

Know your enemy: finding certainty in uncertain times

This blog highlights one of the first studies identifying and characterizing the novel coronavirus, ultimately contributing to the viral genome sequence being shared worldwide.

Screening for the novel coronavirus with one-step RT-qPCR

Learn how researchers identified a novel, highly contagious coronavirus and developed a one-step RT-qPCR screening protocol.

Takara Bio plays a crucial role in fighting the novel coronavirus

Learn how Takara employees in Dalian, China, are working tirelessly to keep up with the demand for the one-step PrimeScript RT-PCR kit, a crucial component in the detection of the novel coronavirus.

Entering new worlds while staying in place

Hear how a Product Manager in Europe is adjusting to the changing research market in light of COVID-19.

Working hard to meet production demands for SARS-CoV-2 testing

Hear how a Takara Bio employee of 27 years is contributing to the COVID-19 effort.

Dethroning king coronavirus with novel vaccines

Find out which types of SARS-CoV-2 vaccines are out there and how Takara Bio is joining the fight.

COVID-19 drug discovery

Our hiPSC-derived cells and other cell biology research products help you study SARS-CoV-2 infection, identify potential targets for drug discovery, evaluate the metabolism and safety of candidate drugs, and develop therapeutic approaches for COVID-19.

Takara Bio products in COVID-19 publications

An ever-growing compilation of COVID-19 publications using Takara Bio products and technologies.

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Takara Bio USA, Inc. provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, Takara Bio USA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

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  • CRISPR screening
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