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  • ‹ Back to Cancer research
  • Kickstart your cancer research with long-read sequencing
  • Sample prep from FFPE tissue
  • Sample prep from plasma
  • Cancer biomarker quantification
  • Single cancer cell analysis
  • Cancer transcriptome analysis
  • Cancer genomics and epigenomics
  • HLA typing in cancer
  • Gene editing for cancer therapy/drug discovery
Chromatin mapping using the ICELL8 system Epigenomic profiling in single cells

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Home › Applications › Cancer research › Single cancer cell analysis

Cancer research

  • Kickstart your cancer research with long-read sequencing
  • Sample prep from FFPE tissue
  • Sample prep from plasma
  • Cancer biomarker quantification
  • Single cancer cell analysis
  • Cancer transcriptome analysis
  • Cancer genomics and epigenomics
  • HLA typing in cancer
  • Gene editing for cancer therapy/drug discovery
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Chromatin mapping using the ICELL8 system Epigenomic profiling in single cells

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Single cancer cell analysis

Key genomic alterations of cancer cells can be structural, including deletions, translocations, or amplification of genes/portions of the genome, or can affect the DNA sequence itself, as with mutations. Cancer progression can be caused by clonal expansion and selection of these driver mutations, resulting in a plethora of malignant alterations characterizing the tumoral DNA. Recent advances in NGS have made it possible to profile the genomes of single tumor cells, allowing systematic documentation of cancer cells' mutational DNA makeup; tracking of clonal and subclonal heterogeneity, generation, and phylogeny; and monitoring of the effects of anticancer therapies at a single-cell level (Van Loo and Voet, 2014). The complexity and heterogeneity of tumor cells also translate at the transcriptomic level, where genomic heterogeneity is mirrored by single-cell variations within the transcriptomes of cancer cells, cancer persister cells, and circulating tumor cells (CTCs).

Studying single cells from precious samples such as cancer persister cells and CTCs requires extraordinarily sensitive and reproducible methodologies. Therefore, the accurate capture and quantification of RNA transcript variations from single tumor cells remains a significant challenge, but would allow researchers to gain insights into tumor complexity and ultimately help in the development of tailored anticancer therapies (Zhu et al. 2017).

Highlighted products

Single-cell genome sequencing

PicoPLEX WGA and DNA-Seq kits, as well as the new PicoPLEX Gold Single Cell DNA-seq Kit, use our patented PicoPLEX technology for single-cell whole genome amplification, which uses multiple cycles of quasi-random priming for reproducible library construction, suitable for sequencing on Illumina platforms. Indeed, our PicoPLEX technology allows the precise and impartial analysis of the genome for many applications in cancer research, including the study of chromosomal aneuploidies, copy number variations (CNVs), single nucleotide variations (SNVs), and the detection of insertions/deletions (Figure 1). Many publications have cited the use of the PicoPLEX technology for high-performance CNV analysis, and the genomic profiling of single cells from FFPE tumor tissues and CTCs. Moreover, our PicoPLEX technology is a vital component of the recently developed single-cell Genome & Transcriptome-seq approach (G&T-seq; Babayan et al. 2017, Cayrefourcq et al. 2015, Lieselot et al. 2017, Macaulay et al. 2015, Morrow et al. 2016, Premasekharan et al. 2016, and Williamson et al. 2016).

CNV detection using PicoPLEX Gold

Figure 1. CNVs detected in two individual cells using the PicoPLEX Gold Single Cell DNA-seq Kit. Log2 ratio of the total number of reads in 50-kb bins from single NCI-H929 cells, shown as one cell in Panel A and a second cell in Panel B. Red bars represent copy-number gains while blue bars represent losses. The top row of the graphs in each panel depicts the control bulk sample sequenced to a depth of 90 million read pairs. The highly reproducible coverage of the PicoPLEX Gold kit enables the accurate detection of structural variants as small as 100 kb, even at shallow sequencing depths (2.5–8.5 million read pairs).

We have always been at the forefront of single-cell mRNA-seq research by leveraging our patented SMART-Seq technology to provide NGS kits with the capability to obtain full-length mRNA sequence information, including splice junction/alternative transcript information, from single cells. Our fourth-generation SMART-Seq v4 Ultra Low Input RNA Kit for Sequencing and the high-throughput SMART-Seq HT Kit represent our most sensitive mRNA-seq solutions for single cells, a few cells, and ultra-low inputs of RNA. These kits rely on oligo(dT) priming and proprietary SMART (Switching Mechanism at 5' end of RNA Template) technology to ensure full-length, unbiased mRNA coverage. Intact cells can be used directly as input for these kits, guaranteeing high-quality input RNA and full-length cDNA coverage. Our SMART-Seq v4 technology is now also fully integrated into the Apollo Library Prep System and the ICELL8 Single-Cell System, our advanced automation platform for high-throughput single-cell analysis. Moreover, many publications have cited the use of our SMART-Seq solutions for single-cell RNA-seq in various cancer applications, including profiling tumor cells and tumor-infiltrating immune cells, analyzing cancer stem cell heterogeneity, identifying tumor cell clones resistant to therapy, and simultaneous sequencing of genome and transcriptome in cancer cells (Chung et al. 2017, Chiu et al. 2018, Han et al. 2018, Kim et al. 2015, and Zheng et al. 2018).

Finally, the SMART-Seq Stranded Kit enables the generation of stranded Illumina-compatible sequencing-ready libraries at the single-cell level. This kit combines features of our SMART-Seq v4 technology with the unique features of our referenced SMARTer Stranded Total RNA-Seq Kit v2 - Pico Input Mammalian Kit, suitable for library preparation from picogram input amounts of tumor total RNA including very degraded FFPE samples from tumor samples.


References and publications citing the use of SMART-seq solutions for single-cell RNA-seq and PicoPLEX solutions for single-cell DNA-seq in various cancer applications

Babayan, A. et al. Comparative study of whole genome amplification and next-generation sequencing performance of single cancer cells. Oncotarget 8, 56066–56080 (2017).

Cayrefourcq, L. et al. Establishment and Characterization of a Cell Line from Human Circulating Colon Cancer Cells. Cancer Res. 75, 892–901 (2015).

Chiu, H. S. et al. Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context. Cell Rep. 23, 297–312 (2018).

Chung, W. et al. Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer. Nature Comm. 8, 15081 (2017).

Han, K. Y. et al. SIDR: simultaneous isolation and parallel sequencing of genomic DNA and total RNA from single cells. Genome Res. 28, 75–87 (2018).

Kim, K. T. et al. Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells. Genome Biol. 16, 127 (2015).

Lieselot, D. et al. Performance of four modern whole genome amplification methods for copy number variant detection in single cells. Sci. Rep. 7, 3422 (2017).

Macaulay, I. C. et al. G&T-seq: parallel sequencing of single-cell genomes and transcriptomes. Nature Methods 12, 519–522 (2015).

Morrow, C. J. et al. Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study. Ann. Oncol. 27, 1155–1160 (2016).

Premasekharan, G. et al. An improved CTC isolation scheme for pairing with downstream genomics: Demonstrating clinical utility in metastatic prostate, lung and pancreatic cancer. Cancer Letters 380, 144–152 (2016).

Van Loo, P. & Voet, T. Single-cell analysis of cancer genomes. Current Opinion in Genetics & Development 24, 82–91 (2014).

Williamson, S. C. et al. Vasculogenic mimicry in small cell lung cancer. Nature Comm. 7, 13322 (2016).

Zheng, H. et al. Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma. Hepatology doi: 10.1002/hep.29778 (2018).

Zhu, S. et al. Advances in single-cell RNA sequencing and its applications in cancer research. Oncotarget 16, 53763–53779 (2017).


Featured products

Cat. # Product Size Price License Quantity Details
R300671 PicoPLEX® Single Cell WGA Kit 24 Rxns USD $648.00

License Statement

ID Number  
328 This Product is protected by one or more patents from the family consisting of: CH1604040, CH2374900, US8206913, US10837049, US11661628, US11492663, DE602004029560.4, DE602004049599.9, DK1604040, DK2374900, EP1604040, EP2374900, FR1604040, FR2374900, UK1604040, UK2374900, HK1089485, IE1604040, IE2374900, JP4773338, NL1604040, NL2374900, SE1604040, SE2374900 and any corresponding patents, divisionals, continuations, patent applications and foreign filings sharing common priority with the same family.

The PicoPLEX Single Cell WGA Kit uses a single-tube protocol developed specifically for reproducible amplification of single-copy genomic DNA (gDNA) starting with 1–10 cells or equivalent picogram quantities of isolated gDNA. Cell lysis and whole-genome preamplification are followed by amplification, which results in libraries with very low background and typical yields of 8–12 µg of product in under 3 hours. This system is best suited for applications in which high yield is most important. This product contains reagents for 24 reactions.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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R300671: PicoPLEX Single Cell WGA Kit

R300671: PicoPLEX Single Cell WGA Kit
R300669 PicoPLEX® Gold Single Cell DNA-seq Kit 24 Rxns USD $1180.00

License Statement

ID Number  
325 Patent pending. For further information, please contact a Takara Bio USA licensing representative by email at licensing@takarabio.com.
M54 This product is covered by the claims of U.S. Patent Nos. 7,704,713 and its foreign counterparts. 
328 This Product is protected by one or more patents from the family consisting of: CH1604040, CH2374900, US8206913, US10837049, US11661628, US11492663, DE602004029560.4, DE602004049599.9, DK1604040, DK2374900, EP1604040, EP2374900, FR1604040, FR2374900, UK1604040, UK2374900, HK1089485, IE1604040, IE2374900, JP4773338, NL1604040, NL2374900, SE1604040, SE2374900 and any corresponding patents, divisionals, continuations, patent applications and foreign filings sharing common priority with the same family.

The PicoPLEX Gold Single Cell DNA-Seq Kit is designed to generate high-quality DNA libraries from single cells for sequencing on Illumina platforms. The kit is based on innovative PicoPLEX technology and yields libraries with superior reproducibility from 1–5 mammalian cells or genome equivalents of gDNA as input, providing reliable results from challenging samples such as formalin-fixed single cells. Single index and unique dual index kits are available and must be purchased separately. This product contains reagents for 24 reactions.

The kit features a streamlined workflow consisting of four steps—from input to amplified NGS libraries—that can be completed in less than four hours. The kit uses high-fidelity enzymes and optimized primers and is suitable for accurate and reproducible profiling of copy number variants (CNVs), single-nucleotide variants (SNVs), indels, and other small structural variants. The kit is compatible with single cells and purified DNA from humans, animals, and bacteria, as well as single flow-sorted chromosomes.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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R300669: PicoPLEX Gold Single Cell DNA-seq Kit

R300669: PicoPLEX Gold Single Cell DNA-seq Kit

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PicoPLEX Gold Single Cell DNA-Seq technology: a four-step reaction that starts with a single cell

PicoPLEX Gold Single Cell DNA-Seq technology: a four-step reaction that starts with a single cell

PicoPLEX Gold Single Cell DNA-Seq technology: a four-step reaction that starts with a single cell. Cellular gDNA extracted in Step 1 is used as template for multiple cycles of quasi-random priming and linear amplification followed by exponential library amplification.

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PicoPLEX Gold Single Cell DNA-Seq Kit workflow

PicoPLEX Gold Single Cell DNA-Seq Kit workflow

PicoPLEX Gold Single Cell DNA-Seq Kit workflow. The four-step PicoPLEX Gold Single Cell DNA-Seq workflow takes place in two tubes or plates and is completed in less than 3 hours with just 30 minutes of hands-on time.

634888 SMART-Seq® v4 Ultra® Low Input RNA Kit for Sequencing 12 Rxns USD $1177.00

License Statement

ID Number  
275 SMART-Seq2 Technology. This product is sold under exclusive license from Ludwig Institute of Cancer Research, Ltd. and is covered by US Patent No. 10266894, Japanese Patent No. 6336080, and European Patent No. 3036336, and pending U.S. patent application and/or pending claims of foreign counterparts. For license information, please contact a Takara Bio USA, Inc. licensing representative by e-mail at licensing@takarabio.com.

The SMART-Seq v4 Ultra Low Input RNA Kit for Sequencing generates high-quality cDNA from ultra-low amounts of total RNA or directly from multiple intact cells (<1,000 cells). This kit can accommodate an input volume of 10 μl and is regularly tested with 10 pg of total RNA. cDNA libraries generated by this kit have been tested for compatibility with Ion Torrent and Illumina sequencing platforms. This kit supports up to 12 reactions.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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634888: SMART-Seq v4 Ultra Low Input RNA Kit for Sequencing

634888: SMART-Seq v4 Ultra Low Input RNA Kit for Sequencing

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Reproducibility is high for low-input samples

Reproducibility is high for low-input samples

Reproducibility is high for low-input samples. FPKMs from replicate libraries generated from 10 pg of Mouse Brain Total RNA using SMART-Seq mRNA (an equivalent replacement for SMART-Seq v4), the SMARTer Ultra Low v3 kit, or the SMART-Seq2 method were compared. For transcripts with FPKM <100, the correlation between replicates was much higher for the SMART-Seq v4 kit (Pearson R = 0.739; Panel B) compared to the SMARTer Ultra Low v3 (Pearson R = 0.376; Panel A) or the SMART-Seq2 method (Pearson R = 0.496; Panel C). For all transcripts (shown in the scatterplots on the right) the correlation between replicates was high for each of the three methods (Pearson R between 0.911-0.972), though SMART-Seq mRNA did have the highest correlation. Transcripts represented in only one replicate can be seen along the X- and Y-axes of the scatter plots showing all transcripts.

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Gene body coverage is good for all three library preparation methods

Gene body coverage is good for all three library preparation methods

Gene body coverage is good for all three library preparation methods. Gene body coverage shown is the average of two replicate libraries prepared from 10 pg Mouse Brain Total RNA using the three different cDNA synthesis methods. The SMARTer Ultra Low v3 kit produced a slight 3' bias, and the SMART-Seq mRNA (an equivalent replacement for SMART-Seq v4) produced a slight 5' bias; however, the overall coverage was fairly even.

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Higher sensitivity and better mappability with SMART-Seq mRNA (an equivalent replacement for SMART-Seq v4).

Higher sensitivity and better mappability with SMART-Seq mRNA (an equivalent replacement for SMART-Seq v4).

Higher sensitivity and better mappability with the SMART-Seq mRNA (an equivalent replacement for SMART-Seq v4 kit). Replicate libraries were generated from 10 pg Mouse Brain Total RNA using SMART-Seq mRNA, the SMARTer Ultra Low v3 kit, or the SMART-Seq2 method. 18 PCR cycles were used to amplify cDNA libraries with the SMART-Seq2 method and SMARTer Ultra Low v3 kit; however, only 17 PCR cycles were needed for the SMART-Seq mRNA libraries.

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Sequencing metrics are consistent across RNA input amounts

Sequencing metrics are consistent across RNA input amounts

Sequencing metrics are consistent across RNA input amounts. 10 pg-10 ng of Human Brain Total RNA were used to generate cDNA libraries in duplicate with the SMART-Seq mRNA kit (an equivalent replacement for SMART-Seq v4). cDNA libraries were amplified using 17, 14, 10, or 7 PCR cycles for the 10 pg, 100 pg, 1 ng, or 10 ng libraries, respectively.

634437 SMART-Seq® HT Kit 96 Rxns USD $2895.00

License Statement

ID Number  
275 SMART-Seq2 Technology. This product is sold under exclusive license from Ludwig Institute of Cancer Research, Ltd. and is covered by US Patent No. 10266894, Japanese Patent No. 6336080, and European Patent No. 3036336, and pending U.S. patent application and/or pending claims of foreign counterparts. For license information, please contact a Takara Bio USA, Inc. licensing representative by e-mail at licensing@takarabio.com.
388 This Product is protected by one or more patents from the family consisting of: US10266894, CA2921603, EP3036336, JP6336080, JP6603699 and any corresponding patents, divisionals, continuations, patent applications and foreign filings sharing common priority with the same family.
442 This Product is protected by one or more patents from the family comprising: US11479806, People's Republic of China Patent: ZL201780061724.9, DE602017050404.1, EP3538662, FR3538662, UK3538662, JP7050057, SE3538662 and any corresponding patents, divisionals, continuations, patent applications and foreign filings sharing priority with the same family.

The SMART-Seq HT Kit is an automation-friendly kit designed for the synthesis of high-quality cDNA directly from 1–100 intact cells or ultra-low amounts of total RNA (10–1,000 pg). cDNA libraries generated with this kit have been tested for compatibility with Illumina sequencing platforms. This kit supports up to 96 reactions.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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634437: SMART-Seq HT Kit

634437: SMART-Seq HT Kit

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Gene expression data obtained from FACS-sorted 293T cells

Gene expression data obtained from FACS-sorted 293T cells

High reproducibility of gene expression data obtained from FACS-sorted 293T cells using SMART-Seq mRNA (equivalent replacement for SMART-Seq v4) and SMART-Seq mRNA HT (equivalent replacement for the SMART-Seq HT Kit). Libraries generated from twenty-one individual 293T cells (table, top panel) were further analyzed to evaluate the reproducibility of gene expression measurements obtained for each cell with the SMART-Seq v4 kit (SSv4_1 to SSv4_12) and the SMART-Seq HT Kit (HT_1 to HT_9)(lower panel). The hierarchical clustering heat map shows Euclidean distances between all the cells and reports Pearson correlations ranging from 0.74 to 0.97. While the best correlations are observed between cells prepared with one or the other kit, the correlations are still very high between the two kits and the cells are not clustering based on the library preparation method. These data demonstrate that the modified workflow in the SMART-Seq HT Kit does not introduce major bias in measurement of gene expression levels. Data is shown for the SMART-Seq v4 and SMART-Seq HT Kit. SMART-Seq mRNA HT is an equivalent replacement for the SMART-Seq HT Kit and SMART-Seq mRNA is an equivalent replacment for SMART-Seq v4.

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Comparison of expression level by gene GC content between SMART-Seq mRNA HT (equivlent to the SMART-Seq HT Kit) and SMART-Seq mRNA (equivalent to SMART-Seq v4)

Comparison of expression level by gene GC content between SMART-Seq mRNA HT (equivlent to the SMART-Seq HT Kit) and SMART-Seq mRNA (equivalent to SMART-Seq v4)

Comparison of expression level by gene GC content between SMART-Seq mRNA HT (equivalent to the SMART-Seq HT Kit) and SMART-Seq mRNA (equivalent to SMART-Seq v4). The libraries made from 10 pg of Mouse Brain Total RNA shown in the table (Figure 2) were further analyzed for GC content representation (see table, top panel). Genes were binned by GC content, and correlation plots were used to visualize the reproducibility of the expression levels (FPKM) of genes in each bin. The average gene counts are very reproducible for replicate samples analyzed using the SMART-Seq v4 (Panel A) or SMART-Seq HT kits (Panel B). Genes with high or low GC content (shown in red and blue, respectively) show similar expression levels in the SMART-Seq v4 and SMART-Seq HT kits (Panel C). Thus, the One-Step RT PCR reaction introduced in the new SMART-seq HT Kit maintains the representation of the low- and high-GC content genes. Data is shown for the SMART-Seq HT Kit and SMART-Seq v4. SMART-Seq mRNA HT is an equivalent replacement for the SMART-Seq HT Kit and SMART-Seq mRNA is an equivalent replacement for SMART-Seq v4.

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High overlap of transcripts identified with SMART-seq mRNA HT (equivalent replacment for the SMART-Seq HT Kit) and SMART-Seq mRNA (equivalent replacment for SMART-Seq v4)

High overlap of transcripts identified with SMART-seq mRNA HT (equivalent replacment for the SMART-Seq HT Kit) and SMART-Seq mRNA (equivalent replacment for SMART-Seq v4)

High overlap of transcripts identified with SMART-seq mRNA HT (equivalent replacment for the SMART-Seq HT Kit) and SMART-Seq mRNA (equivalent replacment for SMART-Seq v4). Libraries prepared from 10 pg of Mouse Brain Total RNA shown in Table 1 were further evaluated for the overlap in the number of transcripts identified (FPKM >0.1) between technical replicates within each kit, and found to be very similar (61–63% overlap) (Panel A). Transcripts identified by all three replicates for each kit were then compared against each other, indicating an overlap of 71%. The overlapping transcripts have an average expression level of 37 FPKM, while the transcripts uniquely identified with individual kits are less abundant, averaging between 6–7 FPKM, indicating that the transcripts more likely to not be identified are the ones expressed at a low level. Data is shown for the the SMART-Seq HT Kit and SMART-Seq v4. SMART-Seq mRNA HT is an equivalent replacement for the SMART-Seq HT Kit and SMART-Seq mRNA is an equivalent replacment for SMART-Seq v4.

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Schematic of technology in SMART-Seq mRNA HT (equivalent replacement for the SMART-Seq HT Kit)

Schematic of technology in SMART-Seq mRNA HT (equivalent replacement for the SMART-Seq HT Kit)

Schematic of technology in SMART-Seq mRNA HT (equivalent replacement for the SMART-Seq HT Kit). SMART technology is used in a ligation-free workflow to generate full-length cDNA. The reverse transcriptase (RT) adds non-templated nucleotides (indicated by Xs) which hybridize to the SMART-Seq HT Oligonucleotide, providing a new template for the RT. Chemical modifications to block ligation during sequencing library preparation are present on some primers (indicated by black stars). The SMART adapters, added by the oligo (dT) primer (SMART-Seq CDS Primer IIA) and SMART-Seq HT Oligonucleotide and used for amplification during PCR, are indicated in green. The one-step RT-PCR is set up as a single reaction so that all the reagents are mixed together but then used sequentially. SeqAmp polymerase is a hot-start DNA polymerase and is activated only after the reverse transcription/template-switching step is complete. Please note that SMART-Seq mRNA HT is an equivalent replacement for the SMART-Seq HT Kit, and uses the same workflow.

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Comparison of the SMART-Seq mRNA HT (equivalent replacement for the SMART-Seq HT Kit) and SMART-Seq mRNA (equivalent replacement for SMART-Seq v4) workflows

Comparison of the SMART-Seq mRNA HT (equivalent replacement for the SMART-Seq HT Kit) and SMART-Seq mRNA (equivalent replacement for SMART-Seq v4) workflows

Comparison of the SMART-Seq mRNA HT (equivalent replacement for the SMART-Seq HT Kit) and SMART-Seq mRNA (equivalent replacement for SMART-Seq v4) workflows. The SMART-Seq v4 method (left) was modified to generate a simplified, high-throughput workflow (SMART-Seq HT Kit, right) with very little hands-on time. Once single cells have been obtained using FACS, the SMART-Seq HT Kit involves only three hands-on steps, while the original SMART-Seq v4 kit involves six hands-on steps. One key step in the SMART-Seq HT workflow is the One-Step RT-PCR, performed using the One-Step RT-PCR Buffer, formulated specifically for optimal reverse transcription followed by efficient PCR cDNA amplification. The One-Step RT-PCR Buffer is directly compatible with AMPure bead purification without the need for additional of Lysis Buffer. As with the original SMART-Seq v4 kit, the SMART-Seq HT Kit requires validation (quantification and assessment of high molecular weight, full-length cDNA) before cDNA is used for sequencing library preparation (Nextera XT). Please note that SMART-Seq mRNA HT is an equivalent replacement for the SMART-Seq HT Kit and SMART-seq mRNA is an equivalent replacement for SMART-Seq v4, and use the same workflows, respectively.

640170 SMART-Seq® v4 Reagent Kit for the Apollo™ System 96 Rxns USD $6633.00

License Statement

ID Number  
275 SMART-Seq2 Technology. This product is sold under exclusive license from Ludwig Institute of Cancer Research, Ltd. and is covered by US Patent No. 10266894, Japanese Patent No. 6336080, and European Patent No. 3036336, and pending U.S. patent application and/or pending claims of foreign counterparts. For license information, please contact a Takara Bio USA, Inc. licensing representative by e-mail at licensing@takarabio.com.

The SMART-Seq v4 Reagent Kit for the SMARTer Apollo System is designed to generate high-quality cDNA from 10 pg–10 ng of total RNA or directly from 1–1,000 cells. This kit is specifically formulated for the SMARTer Apollo system, enabling processing of up to 96 samples in a single working day with minimal hands-on time. cDNA produced with the kit can be used to construct RNA-seq libraries that are compatible with Illumina® or Ion Torrent platforms, and that provide industry-leading sensitivity and accurate representation of rare and GC-rich transcripts.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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640170: SMART-Seq v4 Reagent Kit for the SMARTer Apollo System

640170: SMART-Seq v4 Reagent Kit for the SMARTer Apollo System
640202 SMART-Seq® ICELL8® Reagent Kit 1 Chip USD $584.00

License Statement

ID Number  
442 This Product is protected by one or more patents from the family comprising: US11479806, People's Republic of China Patent: ZL201780061724.9, DE602017050404.1, EP3538662, FR3538662, UK3538662, JP7050057, SE3538662 and any corresponding patents, divisionals, continuations, patent applications and foreign filings sharing priority with the same family.

SMART-Seq ICELL8 reagent kits, available for purchase separately, combine with indexing primer sets (SMART-Seq ICELL8 Indexing Primer Set – A [Cat. No. 640205] and/or SMART-Seq ICELL8 Indexing Primer Set - B [Cat. No. 640218]) and ICELL8 250v chips (Cat. No. 640183) or ICELL8 350v chips (Cat. No. 640019) for use with the SMART-Seq ICELL8 or ICELL8 cx application protocols, respectively. These protocols enable users to analyze full-length transcripts using ICELL8 single-cell systems. This kit (Cat. No. 640202) contains reagents sufficient for running one chip.

The protocols for performing SMART-Seq chemistry on ICELL8 systems leverage SMART technology for full-length cDNA synthesis and Nextera® technology for Illumina library preparation with dual 72 x 72 indexes (Nextera Tagment DNA Enzyme not included). The protocols generate indexed libraries that are ready for sequencing on Illumina platforms.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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640202: SMART-Seq ICELL8 Reagent Kit

640202: SMART-Seq ICELL8 Reagent Kit
634442 SMART-Seq® Stranded Kit 12 Rxns USD $1150.00

License Statement

ID Number  
395
This Product is protected by one or more patents from the family consisting of: US10150985, CA2939621, People's Republic of China Patent: ZL201480077658.0, US10988796, DE602014058059.9, EP3105325, FR3105325, UK3105325, JP6416939 and any corresponding patents, divisionals, continuations, patent applications and foreign filings sharing common priority with the same family.  Additional information may be found at https://www.takarabio.com/patents. 
425 LIMITED USE LABEL LICENSE: RESEARCH USE ONLY Notice to Purchaser: This product is the subject to a license granted to Takara Bio USA, Inc. and its Affiliates from Caribou Biosciences, Inc., and this product is transferred to the end-user purchaser (“Purchaser”) subject to a “Limited Use Label License” conveying to the Purchaser a limited, nontransferable right to use the product, solely as provided to Purchaser, together with (i) progeny or derivatives of the product generated by the Purchaser (including but not limited to cells), and (ii) biological material extracted or derived from the product or its corresponding progeny or derivatives (including but not limited to cells) (collectively, the product, and (i) and (ii) are referred to as “Material”) only to perform internal research for the sole benefit of the Purchaser. The Purchaser cannot sell or otherwise transfer Material to a third party or otherwise use the Material for any Excluded Use. “Excluded Use” means any and all: (a) commercial activity including, but not limited to, any use in manufacturing (including but not limited to cell line development for purposes of bioproduction), product testing, or quality control; (b) preclinical or clinical testing or other activity directed toward the submission of data to the U.S. Food and Drug Administration, or any other regulatory agency in any country or jurisdiction where the active agent in such studies comprises the Material; (c) use to provide a service, information, or data to a third party with the sole exception of using the Material to conduct in vitro sample preparation, i.e., selectively depleting target cDNAs from a sample either by cleaving or selectively separating such target cDNAs from the sample through the use of the Materials; (d) use for human or animal therapeutic, diagnostic, or prophylactic purposes or as a product for therapeutics, diagnostics, or prophylaxis; (e) activity in an agricultural field trial or any activity directed toward the submission of data to the U.S. Department of Agriculture or any other agriculture regulatory agency; (f) high throughput screening drug discovery purposes (i.e., the screening of more than 10,000 experiments per day) as well as scale-up production activities for commercialization; (g) modification of human germline, including editing of human embryo genomes (with the sole exception of editing human embryonic stem (ES) cell lines for research purposes) or reproductive cells; (h) self-editing; and/or (i) stimulation of biased inheritance of a particular gene or trait or set of genes or traits (“gene drive”). It is the Purchaser’s responsibility to use the Material in accordance with all applicable laws and regulations. For information on obtaining additional rights, including commercial rights, please contact licensing@cariboubio.com or Caribou Biosciences, Inc., 2929 7th Street, Suite 105, Berkeley, CA 94710 USA, Attn: Licensing
392 This Product is protected by one or more patents from the family consisting of:US10941397, People's Republic of China Patent: ZL201480057094.4, US10781443, US10954510, DE602014069266.4, EP3058104, FR3058104, UK3058104, JP6602294, SE3058104, CA2923812, and any corresponding patents, divisionals, continuations, patent applications and foreign filings sharing common priority with the same family. Information on relevant patents and licenses for this product may be found at: https://www.takarabio.com/patents. 
450 This Product is sold under license from JumpCode Genomics, Inc., and is covered by one or more of the following US patents and foreign counterparts as well as pending US and foreign patent applications: 10,604,802; 11,708,606; 11,761,039; PCT/US2015/014242; CA2938669; EP 20192599.7; HK402021031164.3.

The SMART-Seq Stranded Kit is used to generate strand-specific RNA-seq libraries for Illumina® sequencing from 1–1,000 sorted cells or 10 pg–10 ng of purified total RNA. This kit incorporates Takara Bio's SMART (Switching Mechanism at the 5' end of RNA Template) technology and includes refinements to the SMARTer method for stranded RNA-seq that simplify the library preparation workflow and improve sequencing performance. In addition, contrary to the SMART-Seq v4 Ultra Low Input RNA Kit for Sequencing and SMART-Seq HT Kit, reverse transcription is initiated using random priming instead of oligo(dT) priming, thus capturing the full transcriptome instead of only the polyadenylated fraction. The SMART-Seq Stranded Kit was specifically designed to deliver highly sensitive and reproducible data from single cells while keeping the workflow short and user friendly. The kit does not require additional rRNA removal methods or kits and produces sequencing libraries that retain strand-of-origin information. The integrated removal of cDNAs derived from rRNA-typically present in high abundance following cDNA synthesis from total RNA inputs-makes the workflow extremely sensitive, yielding data that is highly reproducible with low mapping to rRNA.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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634442: SMART-Seq Stranded Kit

634442: SMART-Seq Stranded Kit

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Takara Bio USA, Inc. provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, Takara Bio USA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

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Takara Bio USA, Inc. provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, Takara Bio USA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES (EXCEPT AS SPECIFICALLY NOTED).

Clontech, TaKaRa, cellartis

  • Products
  • COVID-19 research
  • Next-generation sequencing
  • Real-time PCR
  • Stem cell research
  • mRNA and cDNA synthesis
  • PCR
  • Cloning
  • Nucleic acid purification
  • Gene function
  • Protein research
  • Antibodies and ELISA
  • New products
  • Special offers
  • COVID-19 research
  • Viral detection with qPCR
  • SARS-CoV-2 pseudovirus
  • Human ACE2 stable cell line
  • Viral RNA isolation
  • Viral and host sequencing
  • Vaccine development
  • CRISPR screening
  • Drug discovery
  • Immune profiling
  • Publications
  • Next-generation sequencing
  • Spatial omics
  • RNA-seq
  • DNA-seq
  • Single-cell NGS automation
  • Reproductive health
  • Bioinformatics tools
  • Immune profiling
  • Real-time PCR
  • Great value master mixes
  • Signature enzymes
  • High-throughput real-time PCR solutions
  • Detection assays
  • References, standards, and buffers
  • Stem cell research
  • Media, differentiation kits, and matrices
  • Stem cells and stem cell-derived cells
  • mRNA and cDNA synthesis
  • In vitro transcription
  • cDNA synthesis kits
  • Reverse transcriptases
  • RACE kits
  • Purified cDNA & genomic DNA
  • Purified total RNA and mRNA
  • PCR
  • Most popular polymerases
  • High-yield PCR
  • High-fidelity PCR
  • GC rich PCR
  • PCR master mixes
  • Cloning
  • In-Fusion seamless cloning
  • Competent cells
  • Ligation kits
  • Restriction enzymes
  • Nucleic acid purification
  • Automated platforms
  • Plasmid purification kits
  • Genomic DNA purification kits
  • DNA cleanup kits
  • RNA purification kits
  • Gene function
  • Gene editing
  • Viral transduction
  • Fluorescent proteins
  • T-cell transduction and culture
  • Tet-inducible expression systems
  • Transfection reagents
  • Cell biology assays
  • Protein research
  • Purification products
  • Two-hybrid and one-hybrid systems
  • Mass spectrometry reagents
  • Antibodies and ELISA
  • Primary antibodies and ELISAs by research area
  • Fluorescent protein antibodies
  • Services & Support
  • OEM
  • Instrument services
  • Gene and cell therapy manufacturing
  • Customer service
  • Sales
  • Shipping & delivery
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  • Vector information
  • OEM
  • Portfolio
  • Process
  • Facilities
  • Request samples
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  • Instrument services
  • Apollo services
  • ICELL8 services
  • SmartChip ND system services
  • Gene and cell therapy manufacturing
  • Services
  • Facilities
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  • Make an appointment with your sales rep
  • Online tools
  • GoStix Plus FAQs
  • Vector information
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  • Next-generation sequencing
  • Spatial biology
  • Real-time PCR
  • Nucleic acid purification
  • mRNA and cDNA synthesis
  • PCR
  • Cloning
  • Stem cell research
  • Gene function
  • Protein research
  • Antibodies and ELISA
  • Automation systems
  • Shasta Single Cell System introduction
  • SmartChip Real-Time PCR System introduction
  • ICELL8 introduction
  • Next-generation sequencing
  • RNA-seq
  • Technical notes
  • Technology and application overviews
  • FAQs and tips
  • DNA-seq protocols
  • Bioinformatics resources
  • Webinars
  • Real-time PCR
  • Download qPCR resources
  • Overview
  • Reaction size guidelines
  • Guest webinar: extraction-free SARS-CoV-2 detection
  • Technical notes
  • Nucleic acid purification
  • Nucleic acid extraction webinars
  • Product demonstration videos
  • Product finder
  • Plasmid kit selection guide
  • RNA purification kit finder
  • mRNA and cDNA synthesis
  • mRNA synthesis
  • cDNA synthesis
  • PCR
  • Citations
  • PCR selection guide
  • Technical notes
  • FAQ
  • Cloning
  • Automated In-Fusion Cloning
  • In-Fusion Cloning general information
  • Primer design and other tools
  • In‑Fusion Cloning tips and FAQs
  • Applications and technical notes
  • Stem cell research
  • Overview
  • Protocols
  • Technical notes
  • Gene function
  • Gene editing
  • Viral transduction
  • T-cell transduction and culture
  • Inducible systems
  • Cell biology assays
  • Protein research
  • Capturem technology
  • Antibody immunoprecipitation
  • His-tag purification
  • Other tag purification
  • Expression systems
  • APPLICATIONS
  • Molecular diagnostics
  • mRNA and protein therapeutics
  • Pathogen detection
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  • Alzheimer's disease research
  • Reproductive health technologies
  • Infectious diseases
  • Molecular diagnostics
  • Interview: adapting to change with Takara Bio
  • Applications
  • Solutions
  • Partnering
  • Contact us
  • mRNA and protein therapeutics
  • Characterizing the viral genome and host response
  • Identifying and cloning protein targets
  • Expressing and purifying protein targets
  • Immunizing mice and optimizing vaccines
  • Pathogen detection
  • Sample prep
  • Detection methods
  • Identification and characterization
  • SARS-CoV-2
  • Antibiotic-resistant bacteria
  • Food crop pathogens
  • Waterborne disease outbreaks
  • Viral-induced cancer
  • Immunotherapy research
  • T-cell therapy
  • Antibody therapeutics
  • T-cell receptor profiling
  • TBI initiatives in cancer therapy
  • Cancer research
  • Kickstart your cancer research with long-read sequencing
  • Sample prep from FFPE tissue
  • Sample prep from plasma
  • Cancer biomarker quantification
  • Single cancer cell analysis
  • Cancer transcriptome analysis
  • Cancer genomics and epigenomics
  • HLA typing in cancer
  • Gene editing for cancer therapy/drug discovery
  • Alzheimer's disease research
  • Antibody engineering
  • Sample prep from FFPE tissue
  • Single-cell sequencing
  • Reproductive health technologies
  • Embgenix FAQs
  • Preimplantation genetic testing
  • ESM partnership program
  • ESM Collection Kit forms
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  • Develop vaccines for HIV
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