Using hiPS gene editing to create a tyrosinemia disease model
CRISPR/Cas9 technology enables precise, footprint-free gene editing. By combining CRISPR/Cas9 with human pluripotent stem cells, we can generate disease models that advance our understanding of disease mechanisms and guide development of novel therapeutics. However, creating these models can be quite difficult. Editing genes while concurrently establishing clonal populations can be both inefficient and time consuming.
In this presentation, Dr. Montse Morell talks about the challenges of creating disease models from hiPSCs. She shares a streamlined method for generating iPSC-derived hepatocytes to model tyrosinemia.
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