The gold standard in diabetes modeling and drug discovery involves the use of primary islets of Langerhans—small communities of hormone-producing cells, including insulin-producing beta cells—which are, unfortunately, costly and difficult to obtain. Additionally, primary islets come from donors with different genetic backgrounds, which adds variability to experiments. To address the need for a consistent and reliable source of the beta cells found within these islets, we have developed a standardized differentiation protocol that mimics the typical stages of pancreatic development to create industrial-scale quantities of human hiPS cell-derived beta cells. These beta cells are a powerful alternative to primary islets, as they offer a virtually unlimited source of cells, are easy to culture, and provide reliable and reproducible models for diabetes research and metabolic disease modeling.
Learn more about how our hiPS cell-derived beta cells are suitable for your functional studies, diabetes modeling, and compound screening for insulin secretion and regulation.
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