Stem cell research
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STEM123 antibody citation list
STEM123 antibody (formerly named SC123) is a mouse monoclonal antibody specific to human glial fibrillary acidic protein (GFAP). It does not cross-react with mouse, rat, or monkey tissue. This human-specific antibody enables the quantification of engraftment, survival, and migration of human astrocytes in xenograft models. Read below for a citation list of studies in which STEM123 antibody was used in peer-reviewed basic, translational, preclinical, and biomedical research.
Chen, H. et al. Human-derived neural progenitors functionally replace astrocytes in adult mice. J. Clin. Invest. 125, 1033–42 (2015).
Cummings, B. J., Uchida, N., Tamaki, S. J. & Anderson, A. J. Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function. Neurol. Res. 28, 474–81 (2006).
Cummings, B. J. et al. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc. Natl. Acad. Sci. 102, 14069–14074 (2005).
Doerr, J. et al. Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy. Mol. Ther. 23, 1519–31 (2015).
Fujimoto, Y. et al. Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells. Stem Cells 30, 1163–73 (2012).
Gorris, R. et al. Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes. Glia 63, 2152–2167 (2015).
Gowing, G. et al. Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats. Neuroreport 25, 367–72 (2014).
Haidet-Phillips, A. M. et al. Human glial progenitor engraftment and gene expression is independent of the ALS environment. Exp. Neurol. 264, 188–99 (2015).
Haus, D. L. et al. CD133-enriched Xeno-Free human embryonic-derived neural stem cells expand rapidly in culture and do not form teratomas in immunodeficient mice. Stem Cell Res. 13, 214–26 (2014).
Krencik, R. et al. Dysregulation of astrocyte extracellular signaling in Costello syndrome. Sci. Transl. Med. 7, 286ra66 (2015).
Lee, H. et al. Human fetal brain-derived neural stem/progenitor cells grafted into the adult epileptic brain restrain seizures in rat models of temporal lobe epilepsy. PLoS One 9, e104092 (2014).
McGill, T. J. et al. Transplantation of human central nervous system stem cells - neuroprotection in retinal degeneration. Eur. J. Neurosci. 35, 468–77 (2012).
Piltti, K. M., Salazar, D. L., Uchida, N., Cummings, B. J. & Anderson, A. J. Safety of epicenter versus intact parenchyma as a transplantation site for human neural stem cells for spinal cord injury therapy. Stem Cells Transl. Med. 2, 204–16 (2013).
Piltti, K. M., Salazar, D. L., Uchida, N., Cummings, B. J. & Anderson, A. J. Safety of human neural stem cell transplantation in chronic spinal cord injury. Stem Cells Transl. Med. 2, 961–74 (2013).
Salazar, D. L., Uchida, N., Hamers, F. P. T., Cummings, B. J. & Anderson, A. J. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One 5, e12272 (2010).
Sareen, D. et al. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. J. Comp. Neurol. 522, 2707–28 (2014).
Sontag, C. J. et al. Immunosuppressants affect human neural stem cells in vitro but not in an in vivo model of spinal cord injury. Stem Cells Transl. Med. 2, 731–44 (2013).
Sontag, C. J., Uchida, N., Cummings, B. J. & Anderson, A. J. Injury to the spinal cord niche alters the engraftment dynamics of human neural stem cells. Stem cell reports 2, 620–32 (2014).
Tamaki, S. J. et al. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell 5, 310–9 (2009).
Uchida, N. et al. Human neural stem cells induce functional myelination in mice with severe dysmyelination. Sci. Transl. Med. 4, 155ra136 (2012).
Zhang, P.-W. et al. Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology. Glia 64, 63–75 (2016).
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