Creating and screening for SNPs
One of the most powerful applications of genome editing technology involves the introduction of single-nucleotide substitutions at specific genomic sites to mimic single-nucleotide polymorphisms (SNPs) implicated in human diseases or to introduce stop codons that yield precise gene knockouts. However, screening hundreds of clones for a single-nucleotide edit remains a challenge, especially in the absence of a phenotype. The Guide-it SNP Screening Kit provides the ability to quickly identify edited clones in 96-well plates, employing a simple and rapid workflow that comprises PCR amplification of the genomic target site followed by an enzymatic assay with a fluorescent readout. Click on the links below to learn more.
Watch our webinar and learn how you can easily screen hundreds of clonal cells for SNPs.
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