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Inducible protein stabilization ProteoTuner protein control systems

ProteoTuner citations

ProteoTuner systems allow quick, predictable regulation of protein presence or absence by acting directly on the protein, using a small, cell-permeable synthetic compound. This post-translational regulation offers a number of benefits, from speed and convenience to precise tuning and reversible control. The table below lists many publications that made use of ProteoTuner technology.

Protein(s) regulated with DD Tag + Shield1Organism/cell typeResearch areaPMIDURL
RhoA 3T3-L1 adipocyte cells Cell signaling, cytokine regulation 19101507 Activate RhoA in adipose tissue
TEL-PDGFR beta Ba/F3 cells Cancer biology, oncogenes 19644140 Study the role of receptor tyrosine kinase degradation in cell proliferation
Class II HDAC C2C12 cells Myogenic regulatory factors 17468767 A salt inducible kinase promotes survival of skeletal myocytes.
Ran-GTP COS and NIH3T3 cells Primary cilia, intraflagellar transport, protein localization and transport 20526328 Use RanGTP to regulate ciliary targeting
Rab8a Dictyostelium Exocytosis, membrane fusion 22323285 Regulate Dictyostelium contractile vacuole discharge with Rab8a
GFP EL4 cells Antigen presentation, immunology 21228349 Screen for drugs that inhibit defective ribosomal products (DRiPs)
BAX HCT116 cells Homeostasis, cell metabolism 21289292 Infer a role for BAX in energy production via aerobic respiration
TRPV5 HEK 293 cells Protein control, ion channels 18842822 Rapid control of ion channel expression and function
PTPN2 HEK 293T cells Cancer biology, tumor suppressor proteins 21791476 Identify a tumor supressor role for protein tyrosine phosphatase PTPN2
ZFN HEK 293T, HeLa and NIH3T3 cells Gene expression regulation, ZFN-mediated gene targeting 19214211 Attenuate the cytotoxic effects of zinc finger nucleases (ZFNs)
GFP HeLa and EL4 cells Antigen presentation, immunology 22509014 Study the generation of MHC class I-associated peptides
CaM, Siah-1A HeLa cells Neurobiology, protein trafficking 23152621 Link calmodulin binding to metabotropic glutamate receptor expression
DsRed-Express HeLa cells Protein control, gene expression regulation 18361798 Product overview: Reversible control of protein levels in cells and organisms
Asf1a HeLa cells Protein control, gene expression regulation, cell cycle regulation 19657394 Methods development: Express or deplete proteins on demand
pUL51 Human cytomegalovirus Viral replication 23175377 Screen for antiviral therapy targets (human cytomegalovirus)
HNF4alpha INS-1 cells Protein control, gene expression regulation, apoptosis 19835622 Methods development: Conditional protein stability
YFP, Luciferase, FTL, DHCH1, UGM, GLF Leishmania major Protein control 19383793 Parasitology: Study the LPG pathway and other pathways relevant to parasite survival and virulence
FGF2 MC3T3 cells Skeletal tissue engineering JACS 207:S263 Determine ideal dose and timing for FGF-2 administration to optimize bone regeneration
Peptide aptamers MCF-7 and A375 cells Structure-function studies 21616931 Methods development: Scaffolds for protein binding studies
RSK2 MDCK cells Cell signaling, epithelial-mesenchymal transition 19716794 Identify RAS-stimulated mechanisms for stimulation of motility and invasive properties
UL54, UL79 MRC-5 cells Viral replication, chromatin modification 22761369 Study the heterochromatin to euchromatin switch in human cytomegalovirus
Luciferase Mice Methods development: Regulating protein stability in live animals 20147108 Methods development: Regulating protein stability in live animals
Luciferase Mice, HCT116 cells Protein control, in vivoapplications, gene therapy 18836461 Methods development: Regulating tumor burden in mouse models
Rtel1 Mouse embryonic stem cells Telomere maintenance, DNA replication and repair 22593209 Study the role of helicase RTEL1 in telomerase maintenance and DNA replication
YFP NIH3T3 and HeLa cells Protein control, gene expression regulation 18815033 Methods development: Regulating protein function with FKBP12 and synthetic small molecules
YFP NIH3T3 cells Protein control, gene expression regulation 21768107 Understand how the misfolded proteins are targeted to the ubiquitin-proteasome system
YFP NIH3T3 cells Protein control, gene expression regulation, ProteoTuner assay validation 17603093 Microarray study: Shield1 does not elicit appreciable cellular responses
YFP, GSK-3 beta, Securin, p21, CDK1, CD8 alpha, RhoA NIH3T3, HEK 293T, HeLa, and COS-1 cells Protein control, gene expression regulation 16959577 Methods development: FKBP12 destabilization domains
TDP-43 Neuro2a cells Neurodegenerative disease 23235148 Amyotrophic lateral sclerosis (ALS) disease mechanism
Calpain Plasmodium falciparum Cellular replication, host-parasite interaction 19164769 Parasitology: Identifying calpain as a drug target in Plasmodium falicparum
CDPK5, CDPK4 Plasmodium falciparum Host-parasite interactions 20466936 Parasitology: Understanding the role of the ATP synthase complex in Plasmodium falciparum
ATP synthase genes Plasmodium falciparum Metabolism 21984828 Parasitology: PfCDPK5 plays an essential role during the blood stage of malaria replication (Plasmodium falciparum)
Falcipain-2, YFP Plasmodium falciparum Protein control 17994030 Methods development and Parasitology: Protein destabilization in Plasmodium falciparum
Doc2.1, CDPK4 Plasmodium falciparum Exocytosis 22246776 Parasitology: Host cell invasion and egress in Toxoplasma gondii
UL96 Primary human foreskin-derived fibroblasts Viral assembly 21593167 Human cytomegalovirus translocation from the nucleus to the cytoplasm
UL117 Primary human foreskin-derived fibroblasts Viral replication, DNA synthesis 20333247 Characterize viral blocking of host DNA synthesis (human cytomegalovirus)
ExoY Pulmonary microvascular endothelial cells Bacterial toxicology, Pseudomonas aeruginosa, tau proteins 22637478 The ExoY toxin of Pseudomonas aeruginosa results in intracellular cAMP and cGMP accumulation
15Ink4b RAW 264.7, hematopoietic progenitor cells Differentiation, adaptive immune response 22461492 Implicate a novel function of tumor suppressor p15Ink4b in the adaptive immune response
IE2, IE3, pUL51, pUL77 Recombinant herpesviruses Viral replication 19578384 Methods development and virology: Construction of virus mutants in which amounts of fusion proteins and viral growth can be regulated by Shield1
Rab11b Toxoplasma gondii Vesicle transport 20686666 Parasitology: Vesicular transport from the Golgi to the Inner Membrane Complex of growing daughter parasites
AMA1 Toxoplasma gondii Host-parasite interaction 22523242 Parasitology: Role of conserved transmembrane adhesin AMA1 in host-cell invasion by apicomplexan parasites
IF2K-D Toxoplasma gondii Host-parasite interaction, gene expression regulation 21908594 Parasitology: Identifying factors in Toxoplasma gondii viability
FRM3 Toxoplasma gondii Cytoskeleton dynamics 22210829 Parasitology: Role of formins in gliding motility in Toxoplasma gondii
IMC8, Centrin2 Toxoplasma gondii Cytokinesis 20808817 Parasitology: Cell division in the apicomplexan parasite, Toxoplasma gondii
Rab11a, MyoA Toxoplasma gondii Cellular replication 19165333 Parasitology: Cell division in apicomplexan parasites
GFP, YFP, MyoA, YPT1, Rab11a Toxoplasma gondii Gene expression regulation 17994029 Methods development and parasitology: Rapid control of protein level in Toxoplasma gondii
Tub8, FRM1, FRM2 Toxoplasma gondii Cytoskeleton dynamics 20949068 Parasitology: Role of formin 3 in gliding motility and parasite migration
H-Ras U251 glioblastoma cells Cell death, methuosis, cell signaling 20713492 Cell death: Triggering methuosis with constitutively active Ras
GFP Yeast & mammalian systems Protein folding, aggresomes 22902621 Mild inhibition of translation results in a dramatic reduction in production of misfolded polypeptides in mammalian cells

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