Single-cell whole-genome amplification to rapidly profile crucial mutation events
Single-cell whole-genome amplification has revolutionized the study of individual cell populations but is limited by throughput. With our technology, you can now analyze cell-to-cell variations across 1,500 tumor cells in a single experiment.
This application note explores how the Shasta Whole-Genome Amplification Kit (Shasta WGA) provides unbiased coverage and reliably detects single-nucleotide variations (SNVs) and copy number variations (CNVs) at single-cell resolution. We assess the kit’s effectiveness in answering a key research question: can Shasta WGA differentiate tumor subclones by identifying CNVs in primary cancer cells?
Learn about:
- Analysis of single cells isolated from both tumor tissue and normal adjacent tissue in Stage I and Stage III clear cell renal cell carcinoma
- Pseudobulk SNV analysis revealing potential somatic variations in tumor subclones
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