Protein-protein interactions
Note: D/D Solubilizer (Cat. # 635053, 635054) has been discontinued. Shield1 ligand (Cat. # 632188, 632189) is the recommended replacement and provides equivalent performance for disrupting dimerization of fusion proteins containing the DmrD domain. For questions, please contact Technical Support.
Understanding the complex network of protein-protein interactions that govern cellular biology is the key to understanding the function of genes and discovering novel drug targets for the treatment of cancer, neurodegenerative disease, and other illnesses. iDimerize systems can bring the interaction between any two proteins under real-time control using a nontoxic, cell-permeable small molecule dimerizer. Hundreds of published studies have utilized this rapid and specific technology to dissect individual steps in signal transduction, apoptosis, secretion, and other processes.
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Inducible protein-protein interactions—iDimerize systems
Components and applications of available iDimerize systems.
Inducible systems learning centers
Tet-inducible systems
Tet-On 3G, Tet-One, and Tet-Off systems.
iDimerize systems
Dimerizer ligand-dependent control of protein-protein interactions.
ProteoTuner systems
Shield1 ligand-dependent control of protein stability/degradation.
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