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  • BioView blog
    • Automation
      • Methods of detection for AMR surveillance
      • Optimizing agriculture screening with high-throughput genotyping
      • ICELL8 cx Single-Cell System and combinatorial indexing
      • Full-length scRNA-seq in white adipose tissue
      • Takara Bio Single-Cell Workshop, Spring 2021
      • Big problems from small bugs
      • Better biobanking with high-throughput qPCR
      • Top 5 considerations when automating single-cell sequencing
      • What's inside automated single-cell RNA-seq platforms?
    • Cancer research
      • Arc-well: sequence single-cell DNA from 30-year old FFPE samples
      • When Epstein-Barr virus becomes a chronic menace
      • Amplifying our understanding of breast cancer metastases
      • Cancer immunotherapy
      • Accurate detection of SNVs and CNVs from 5-cell inputs
    • Career spotlights
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      • Career spotlight: senior inside sales representative
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      • Career spotlight: senior lead development representative
      • Career spotlight: technical support scientist
    • Current events
      • National Hispanic Heritage Month
        • 2024
          • Dr. Nick Silva discusses his passion for training and supporting underrepresented students in our first National Hispanic Heritage Month spotlight interview
          • Dr. Loyda Morales Rodriguez discusses her Hispanic heritage and how it drives her passion for increasing diversity and inclusivity in clinical research
          • Dr. Darya Marchany-Rivera speaks about her passion for helping people—including Hispanic students—meet their goals and dreams
          • Dr. Dianne Laboy Cintrón talks about her experience as an underrepresented student—and studying an “underrepresented” part of the human genome
        • 2023
          • Dr. Jose Barbosa
          • Dr. Yadira Soto-Feliciano
          • Dr. Sarah Stewart
      • Identifying promising HIV vaccine strategies
      • Your spit can save your life
      • Controlling the spread of COVID-19 with direct saliva testing
      • The 2020 Nobel Prize in Chemistry for CRISPR
      • In memory of Hermann Bujard
      • Coronavirus publication: know your enemy
      • Dethroning king coronavirus with novel vaccines
      • Entering new worlds while staying in place
      • Working hard to meet production demands for SARS-CoV-2 testing
      • Shelter in place
      • Takara Bio plays a crucial role in fighting the novel coronavirus
      • Screening for novel coronavirus with one-step RT-qPCR: getting ahead of the outbreak
    • Customer stories
      • PrimeSTAR GXL: a decisive component in characterizing viral RNA structures
      • Joining the fight against antibiotic resistance
      • Overcoming technical challenges in extracellular vesicle research
      • Sequencing grey matter
      • Unlocking cardiomyocyte heterogeneity: the role of transcription factors
      • Profiling transcription factors with CUT&RUN sequencing
    • Gene editing
      • Measure twice, cut once
      • Successful knockout experiments part II
      • Successful knockout experiments part I
      • Efficient nonviral T-cell engineering using CRISPR
    • Research news
      • wellDA-seq: bridging the gap between genetic and epigenetic profiling
      • Engineered PsCas9 for therapeutic genome editing
      • Delivery of functionalized DNA origami into the cell nucleus
      • Demystifying and simplifying the lentiviral production and transduction workflow
      • On-demand pharmaceuticals in space
      • Amplify NGS libraries without bias
      • Takara Bio wins a Crabby!
      • A new hiPSC model for type 2 diabetes
      • TCR-seq methods: strengths, weaknesses, and rankings
      • A faster path to analysis for mAbs as therapeutic agents
      • Gene therapy takes a step forward
      • ICELL8 technology keeps cardiovascular research pumping
      • Women's Networking Event at AGBT 2020
      • Detecting infectious disease threats in a changing climate
      • Unraveling the world of microorganisms
      • Microbiomes in the brain and belly
      • Gaining insight into pulmonary arterial hypertension with purified exosomes
      • Total RNA-seq from human biofluids and EVs
      • Seq-ing the small
      • Taking the SMARTer approach to RNA-seq of FFPE tissues
    • Single-cell analysis
      • Optimized full-length single nuclei RNA sequencing (snRNA-seq) to propel crop innovation
      • ABRF publishes single-cell RNA-seq benchmarking study
      • Two RNA-seq approaches reveal resident memory T cells hold the power to reverse liver fibrosis
      • Combination of single-cell RNA-seq approaches yields insights into the brain
      • Combining droplet and full-length sequencing technologies for a complete picture
      • Smashing single-cell sequencing sensitivity
      • Change of heart: exploring transcriptional variation in cardiomyocytes
      • Accelerating chromatin mapping with single-cell ATAC-seq
      • Bringing epigenomic profiling to the single-cell biology stage
      • Using the power of RNA-seq to characterize brain cell types
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      • 20 years of human stem cell research
      • Maximize transduction efficiency in hematopoietic cells
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      • It's a snap! 9 considerations for easy multi-fragment cloning
      • Best practices for RNA-seq: Optimizing sample prep
      • Designing primers for site-directed mutagenesis
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      • Understanding viral titration—behind the science
      • 4 factors to consider for immune repertoire profiling
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Overviews ICELL8 learning resources
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Our history

Takara Bio has over 90 years of experience in pursuing excellence in biochemistry tools. We started in 1925 by improving fermentation techniques for cultivating microbes, and in 1950 we launched a biotech R&D center that yielded cutting-edge advances. Today our extensive portfolio of reagents, instrumentation, and services supports a wide variety of applications, from basic research to routine laboratory testing, for laboratories around the world.

About us

1967: Takara Bio Inc.

Takara Bio Inc. was established as an offshoot of the Takara Shuzo beverage company in 1967. For over 50 years, Takara Bio Inc. has provided a diverse array of biotechnology products and services, including enzymes and reagents, contracted research and production capabilities, nutraceuticals, and gene-based therapies currently under clinical development. In keeping with their commitment to quality, Takara Bio Inc. has achieved ISO 9001:2015 certification.

For much of its history and up to the present day, Takara Bio Inc. has been associated with industry-leading restriction enzymes and PCR polymerases, including current offerings such as Takara Ex Taq, Takara LA Taq, and PrimeSTAR GXL polymerases. The variety of available Takara-brand enzymes provides researchers with tremendous flexibility in selecting the best one for a given application, including those that involve the analysis of technically challenging samples. Takara Bio is also widely recognized for its RetroNectin transduction reagent, which has been used in countless clinical trials and is a worldwide standard for gene therapy protocols.

In addition to products, a variety of services are offered by Takara Bio Inc., including genome sequencing, expression profiling, data mining, technical support for immunotherapy research, and the production of custom reagents for gene therapy. Takara Bio Inc. is currently conducting clinical trials aimed at developing gene-based therapies for diseases such as cancer and AIDS, and the recent construction of a GMP-compliant facility in Kusatsu City, Japan, has enabled Takara Bio Inc. to offer clinical-grade production capabilities.

2005: Acquisition of Clontech Laboratories, Inc.

For over 30 years, Clontech Laboratories, Inc. (now Takara Bio USA, Inc.), has supported the life sciences research community through the development and commercialization of kits and reagents for diverse experimental applications, with emphases in cell and molecular biology. The company was founded in Silicon Valley in 1984 at the height of the molecular biology revolution. Following acquisition by Becton Dickinson (BD) in 1999, Clontech was acquired by Takara Bio in 2005.

Noteworthy product offerings in Clontech's history include reagents and expression systems for analyses of gene function and protein-protein interactions, kits for cDNA synthesis and library construction, cDNA arrays for differential gene expression analysis, and a diverse assortment of widely used fluorescent protein vectors for studies of gene expression and protein localization. More recently, Clontech has been associated with best-in-class tools for next-generation sequencing (SMART,  SMARTer, and SMART-Seq kits) and PCR (Titanium Taq and Advantage 2 polymerases), as well as innovative solutions for cloning and mutagenesis (In-Fusion Cloning systems), protein purification (Capturem technology), and genome editing (Guide-it kits).

In keeping with our commitment to quality, Takara Bio USA, Inc. has achieved ISO 13485:2016 certification.

2014: Acquisition of Cellartis

Cellartis (now Takara Bio Europe AB) was founded by researchers from the University of Gothenburg in 2001 with the objective of providing cutting-edge products for research applications involving stem cells. Following the purchase of Cellartis by Cellectis SA in 2011, Cellartis was acquired by Takara Bio in 2014.

Historically, a primary focus of Cellartis involved developing and distributing stem cell lines—including both human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs)—for general or custom applications. More recently, the scope of offerings expanded to include products such as culture systems, media, and reagents which made Cellartis' expertise and innovative technologies more readily accessible to researchers. An important milestone involved the development and commercialization of the Cellartis DEF-CS culture system, a revolutionary approach to culturing stem cells that offers significant advantages relative to other methods.

2017: Acquisition of Rubicon Genomics, Inc.

Rubicon Genomics, Inc. was founded in 2000 in Ann Arbor, Michigan by two University of Michigan faculty members, Dr. John Langmore and Dr. Vladimir Makarov, with the aim of developing and commercializing nucleic acid library preparation kits that simplify sample processing workflows while providing high sensitivity and reproducibility. The company was acquired by Takara Bio in 2017.

Drawing upon exceptional knowledge of nucleic acid chemistry, enzymology, and sample processing, Rubicon focused on developing kits to enable researchers to examine a variety of challenging samples—FFPE tissue, plasma, and single cells—even when using degraded or small amounts of starting material. Notably, Rubicon developed ThruPLEX, PicoPLEX, and TransPLEX technologies for library preparation from low inputs of fragmented DNA, single cells, and FFPE-derived RNA, respectively.

Moving forward, Takara Bio's NGS portfolio will combine the power of SMART cDNA synthesis technology for RNA-seq applications with Rubicon's ThruPLEX and PicoPLEX technologies for DNA-seq to provide unmatched sensitivity for demanding sequencing applications—regardless of sample or input type.

2017: Acquisition of WaferGen Bio-systems, Inc.

WaferGen Bio-systems, Inc. leveraged expertise in engineering and microfluidics to develop and commercialize automation platforms for high-throughput sample prep and single-cell analysis. The company was founded in 2002 and acquired by Takara Bio in 2017.

WaferGen's flagship ICELL8 technology (now incorporated in Takara Bio's ICELL8 Single-Cell System), provides a novel combination of cell isolation, cell selection, and throughput capabilities that enable researchers to perform single-cell analysis with unparalleled control and reproducibility. The SmartChip qPCR platform can be used for profiling and validating molecular biomarkers and enables massively parallel singleplex PCR for one-step target enrichment and library preparation. Another noteworthy WaferGen product, the Apollo 324 Next Generation Sample Preparation System (now referred to as the "Apollo Library Prep System") provides convenience, flexibility, and reliability for a wide array of sample preparation applications.

With the integration of WaferGen's products and technologies, Takara Bio can now offer complete workflows for automated sample processing and analysis that deliver unmatched ease-of-use and reliability for both basic and clinical research applications.


Takara Bio USA Holdings, Inc. completes acquisition of Rubicon Genomics, Inc.

Mountain View, CA—January 18, 2017—Takara Bio USA Holdings, Inc. ("TBUSH") announced that it has completed the acquisition of Rubicon Genomics, Inc. ("Rubicon"). Rubicon has become a wholly-owned subsidiary of TBUSH as of January 17, 2017 (US local time). The Takara Bio Group provides a wide range of life science products and services under the Takara, Clontech, and Cellartis brands that assist discovery, translational and clinical scientists in the advancement of their work. The Rubicon acquisition will allow the Takara Bio Group to augment and expand its worldwide commercial offerings in next generation sequencing (NGS) sample preparation and expand into new markets.

Read the press release


Takara Bio USA Holdings, Inc. completes acquisition of WaferGen Bio-systems, Inc.

Mountain View, CA—March 1, 2017—Takara Bio USA Holdings, Inc. ("TBUSH") announced that it has completed the acquisition of WaferGen Bio-systems, Inc. ("WaferGen"), WaferGen has become a wholly owned subsidiary of TBUSH as of February 28, 2017 (US local time).

Read the press release

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Takara Bio USA, Inc. provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, Takara Bio USA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

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Takara Bio USA, Inc. provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, Takara Bio USA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES (EXCEPT AS SPECIFICALLY NOTED).

Clontech, TaKaRa, cellartis

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  • Viral detection with qPCR
  • SARS-CoV-2 pseudovirus
  • Human ACE2 stable cell line
  • Viral RNA isolation
  • Viral and host sequencing
  • Vaccine development
  • CRISPR screening
  • Drug discovery
  • Immune profiling
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  • Spatial omics
  • RNA-seq
  • DNA-seq
  • Single-cell NGS automation
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  • Signature enzymes
  • High-throughput real-time PCR solutions
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  • High-fidelity PCR
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