mRNA-Based Therapeutics Summit
Empowering breakthroughs in mRNA therapeutics
The 5th Annual mRNA-Based Therapeutics Summit happened July 21–23 in Boston, MA, and featured insights from mRNA technology experts, including key figures from leading companies, to discuss advancements in mRNA vaccines and therapeutics across various disease areas.
We shared information about our latest innovative technologies that provide support for scientists making breakthroughs at every stage of the mRNA-based therapeutics pipeline, from discovery to delivery.
Poster presentation
Rapid quantitative detection of dsRNA impurities in mRNA therapeutics using a novel lateral flow assay
With this poster, Dr. Yuiko Matsumoto presented a novel method to rapidly quantify dsRNA, using a lateral flow assay that employs K1 and J2 antibodies to detect double-stranded RNA (dsRNA) from in vitro transcription (IVT) samples. IVT for mRNA production can generate dsRNA, which can trigger immune responses and lead to unwanted side effects. The newly developed assay uses 20 µl of sample and delivers results in 10 min via a smartphone app (quantitation limit of 6.25 ng/ml [0.000625% in a 1 mg/ml IVT sample]) with Poly I:C as the standard. The assay is highly specific and reproducible, supporting process monitoring during mRNA manufacturing.
Featured technologies
PrimeCap T7 RNA Polymerase (low dsRNA)
PrimeCap T7 RNA Polymerase (low dsRNA) is a modified form of T7 RNA polymerase that combines highly efficient cap-analog-dependent RNA synthesis with extremely low dsRNA generation, making it the ideal choice for researchers engaged in mRNA therapeutic research and development.
Takara IVTpro mRNA Synthesis System
A complete solution for synthesizing high-quality single-stranded mRNA containing your gene of interest with a cap structure and poly(A) sequence.
mRNA synthesis learning center
Resources for Takara IVTpro mRNA Synthesis System.
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