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Cellartis iPS Cell to Hepatocyte Differentiation System citation list
Hepatocytes derived from human induced pluripotent stem (hiPS) cells using the Cellartis iPS Cell to Hepatocyte Differentiation System are an alternative to primary hepatocytes as they exhibit sufficient expression levels of drug-metabolizing enzymes and transporters and demonstrate stable functionality over time in culture. In addition, hiPS cell-derived hepatocytes can provide an accurate reflection of the metabolic diversity observed in the human population. Cells produced with the system are ideal for disease modeling, in vitro drug discovery and screening, metabolic studies, and toxicity testing. Read below for a citation list of studies in which the Cellartis iPS Cell to Hepatocyte Differentiation System was used in peer-reviewed basic, translational, preclinical, and biomedical research.
Asplund, A. et al. One Standardized Differentiation Procedure Robustly Generates Homogenous Hepatocyte Cultures Displaying Metabolic Diversity from a Large Panel of Human Pluripotent Stem Cells. Stem Cell Rev. 12, 90–104 (2016).
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