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Cellartis Enhanced hiPS-HEP citation list
Cellartis Enhanced hiPS-HEP cells are a highly homogeneous population of hepatocytes derived from human induced pluripotent stem (hiPS) cells. The cells express metabolic enzymes relevant to hepatotoxicity, making them ideal for in vitro drug discovery, drug metabolism, and toxicology-related studies. Read below for a citation list of studies in which Cellartis Enhanced hiPS-HEP cells were used in peer-reviewed basic, translational, preclinical, and biomedical research.
Brolén, G. et al. Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage. J. Biotechnol. 145, 284–94 (2010).
Doktorova, T. Y. et al. Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models. Carcinogenesis 34, 1393–402 (2013).
Ek, M. et al. Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells. Biochem. Pharmacol. 74, 496–503 (2007).
Emgård, M. & Björquist, P. in Regenerative Medicine, Stem Cells and the Liver 59–76 (Science Publishers, 2012). doi:10.1201/b11937-7.
Kia, R. et al. MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity. Toxicol. Sci. 144, 173–85 (2015).
Mandenius, C.-F. et al. Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project. Altern. Lab. Anim. 39, 147–71 (2011).
Norrman, K., Strömbeck, A., Semb, H. & Ståhlberg, A. Distinct gene expression signatures in human embryonic stem cells differentiated towards definitive endoderm at single-cell level. Methods 59, 59–70 (2013).
Sartipy, P. & Björquist, P. Concise review: Human pluripotent stem cell-based models for cardiac and hepatic toxicity assessment. Stem Cells 29, 744–8 (2011).
Sivertsson, L., Synnergren, J., Jensen, J., Björquist, P. & Ingelman-Sundberg, M. Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactor. Stem Cells Dev. 22, 581–94 (2013).
Söderdahl, T. et al. Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells. Toxicol. In Vitro 21, 929–37 (2007).
Synnergren, J. et al. Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further toward the hepatic lineage. Stem Cells Dev. 19, 961–78 (2010).
Tostões, R. M. et al. Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing. Hepatology 55, 1227–36 (2012).
Ulvestad, M., Björquist, P., Molden, E., Asberg, A. & Andersson, T. B. OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture. Biochem. Pharmacol. 82, 1219–26 (2011).
Yildirimman, R. et al. Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol. Sci. 124, 278–90 (2011).
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