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Cellartis enhanced hiPS-HEP iPSC-derived hepatocytes

Cellartis enhanced hiPS-HEP v2 kits provide an inexhaustible supply of mature hepatocytes derived from human induced pluripotent stem (hiPS) cells. hiPS-HEP cells have functional drug-metabolizing machinery over a 14-day assay window, making them ideal for in vitro drug discovery, drug metabolism, and toxicology-related studies. Mature, robust metabolic features support metabolic disease modeling.

The user-friendly kit format includes complete media and components for long-term assays. Compared to other hepatic cell models, these cells survive longer in culture, which enables a longer assay window in chronic toxicity experiments and for metabolic disease modeling.

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Cat. #

Product

Size

License

Quantity

Details

Y10133

Cellartis® Enhanced hiPS-HEP v2 (from ChiPSC12) Kit

1 Kit

USD $1818.00

License Statement

ID Number

C005

This product is manufactured and sold by Takara Bio Europe AB based on a license to Cellectis SA. The use of this product is strictly limited to purchaser’s own internal research, including basic research, drug discovery research up to and including IND-enabling preclinical toxicological studies or equivalents thereof, excluding any use in the T-cell field. Purchaser cannot have any right to use this product or its components in humans for any purposes including but not limited to diagnostics and/or therapeutics, or otherwise clinical trials. Purchase does not include any right to resell or transfer this product to a third party regardless of whether or not compensation is received. Purchasers wishing to use this product for purposes other than internal research use should contact us. No express or implied license is granted to the purchaser.

L67

This product is covered by one or more claims of the issued patents and pending patent applications: U.S. Patent Nos. 8,048,999, 8,058,065, 8,129,187, 8,211,697, 8,257,941, 8,278,104, 8,530,238, 8,900,871, 8,927,277, 8,951,801, 9,213,999, 9,404,124, 9,499,797, 9,677,141, 9,714,433, and 9,938,585 and foreign counterparts thereof, including their divisions, continuations, extensions, substitutions, and those claiming priority therefrom or those claiming the same priorities therein.

This Product is manufactured and sold by Takara Bio Inc. and/or its affiliate(s) based on a patent license from iPS Academia Japan, Inc.

No express or implied license is granted to the purchaser.

"Product" means the differentiated cells manufactured and sold by Takara Bio Inc.

"Internal research purpose" means the use of this Product as a tool of internal research for the sole benefit of the purchaser or purchaser's contract research customer, (including screening of compounds, antibodies, proteins, peptides and others in developing pharmaceuticals (including diagnostic agents) for human and/or animal use), provided, however, that the following activities using this Product are strictly prohibited and expressly excluded from Internal research purposes:

With the exemption for academic and non-commercial clinical research done by non-profit institutions;

1) Administration of this Product to humans.

2) Use of this Product for the diagnostic testing, prevention, or treatment of human and/or animal diseases.

3) Use of this Product in studies involving administration to humans for cell therapy, regenerative medicine etc.

Purchaser may use this Product for its own Internal research purposes.

Purchaser shall not use the Products for its commercial purposes.

Notwithstanding the foregoing, the purchaser of this Product may provide third parties with contract research services by using this Product only for such third party's Internal research purposes.

The Cellartis Enhanced hiPS-HEP v2 (from ChiPSC12) Kit is an optimized, complete system for the long-term maintenance of Cellartis Enhanced hiPS-HEP (from ChiPSC12) cells. These cells, included in the kit, are cryopreserved human hepatocytes derived from the Cellartis human induced pluripotent stem cell line 12 (ChiPSC12). The Cellartis Enhanced hiPS-HEP v2 (from ChiPSC12) Kit also contains a kit for thawing and plating of the cells and a long-term maintenance medium suitable for up to 19 days of cell culture.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Components

Y10134

Cellartis® Enhanced hiPS-HEP v2 (from ChiPSC18) Kit

1 Kit

USD $1818.00

License Statement

ID Number

C005

L67

The Cellartis Enhanced hiPS-HEP v2 (from ChiPSC18) Kit is an optimized, complete system for the long-term maintenance of Cellartis Enhanced hiPS-HEP (from ChiPSC18) cells. These cells, included in the kit, are cryopreserved human hepatocytes derived from the Cellartis human induced pluripotent stem cell line 18 (ChiPSC18). The Cellartis Enhanced hiPS-HEP v2 (from ChiPSC18) Kit also contains a kit for thawing and plating of the cells and a long-term maintenance medium suitable for up to 19 days of cell culture.

Notice to purchaser

Components

Y10135

Cellartis® Enhanced hiPS-HEP v2 (from ChiPSC22) Kit

1 Kit

USD $1818.00

License Statement

ID Number

C005

L67

The Cellartis Enhanced hiPS-HEP v2 (from ChiPSC22) Kit is an optimized, complete system for the long-term maintenance of Cellartis Enhanced hiPS-HEP (from ChiPSC22) cells. These cells, included in the kit, are cryopreserved human hepatocytes derived from the Cellartis human induced pluripotent stem cell line 22 (ChiPSC22). The Cellartis Enhanced hiPS-HEP v2 (from ChiPSC22) Kit also contains a kit for thawing and plating of the cells and a long-term maintenance medium suitable for up to 19 days of cell culture.

Notice to purchaser

Components

Overview

Complete kit for thawing, plating, and culturing the provided cells
Highly homogeneous population with consistent performance between batches and over time
Cells are functional and stable for a 14-day assay window
Cells show long-term, stable CYP450 activities
Cells express key hepatocyte proteins, including α1AT, Alb, CK18, HNF4α, and E-cadherin
Cells secrete physiologically relevant levels of albumin and urea
Cells demonstrate functional insulin and glucose regulation
Cells show Phase I and II enzyme activities
Cells demonstrate LDL uptake

More Information

Applications

Toxicity testing, including chronic toxicity assays
Drug discovery and development
Metabolic studies
Metabolic disease modeling

Components

1 vial of ~1.2 x 10⁷ cells
Hepatocyte thawing medium
Hepatocyte coating
Hepatocyte plating medium
Hepatocyte washing medium
Hepatocyte long-term maintenance medium

Additional information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.

Takara Bio USA, Inc.
United States/Canada: +1.800.662.2566 • Asia Pacific: +1.650.919.7300 • Europe: +33.(0)1.3904.6880 • Japan: +81.(0)77.565.6999
FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. © 2022 Takara Bio Inc. All Rights Reserved. All trademarks are the property of Takara Bio Inc. or its affiliate(s) in the U.S. and/or other countries or their respective owners. Certain trademarks may not be registered in all jurisdictions. Additional product, intellectual property, and restricted use information is available at takarabio.com.

Cellartis enhanced hiPS-HEP iPSC-derived hepatocytes

Notice to purchaser

Cellartis human induced pluripotent stem (iPS) cell-derived hepatocytes are a long-lasting, reliable liver disease model.

CYP450 activity is stable in enhanced hiPS-HEP cells over 21 days.

Notice to purchaser

Cellartis human induced pluripotent stem (iPS) cell-derived hepatocytes are a long-lasting, reliable liver disease model.

CYP450 activity is stable in enhanced hiPS-HEP cells over 21 days.

Albumin is present in enhanced hiPS-HEP cells through 20 days in culture.

Notice to purchaser

Cellartis human induced pluripotent stem (iPS) cell-derived hepatocytes are a long-lasting, reliable liver disease model.

CYP450 activity is stable in enhanced hiPS-HEP cells over 21 days.

Overview

More Information

Applications

Components

Additional information