Embgenix PGT-A Kit (RUO)
The Embgenix PGT-A Kit (RUO) and accompanying analysis software provide a complete research solution for next-generation sequencing (NGS)-based detection of chromosomal copy number variations (CNVs). The kit enables accurate identification of whole-chromosome, segmental, and mosaic aneuploidies, and yields sequencing libraries compatible with multiple platforms in a scalable format to support medium- to high-throughput applications.
The Embgenix PGT-A Kit (RUO) and accompanying analysis software provide a complete research solution for next-generation sequencing (NGS)-based detection of chromosomal copy number variations (CNVs). The kit enables accurate identification of whole-chromosome, segmental, and mosaic aneuploidies, and yields sequencing libraries compatible with multiple platforms in a scalable format to support medium- to high-throughput applications.
The kit employs PicoPLEX technology for highly reproducible whole genome amplification (WGA) and a streamlined library prep methodology that minimizes hands-on time and the likelihood of research sample processing errors. PicoPLEX WGA is a widely applied technology for CNV detection from single cells and low-input DNA in the context of reproductive health research. The entire library preparation workflow can be completed in a single tube in about two hours, yielding NGS libraries that are broadly compatible with multiple sequencing platforms and allow for multiplexing of up to 96 samples per sequencing run.
After sequencing, cloud-based Embgenix Analysis Software (RUO) is used for data analysis and reporting. The software’s algorithm is designed to compute calculated copy numbers (CCNs) using bin counts against an internally configured reference for accurate determination of chromosomal CNVs. The software supports both automated and manual calling of whole chromosome, segmental, and mosaic CNVs, and data can be conveniently visualized in a chart or an idiogram plot. The software also provides a variety of data output options, including bulk download of results and generation of customizable PDF reports.
Overview
- Complete research solution for NGS-based CNV detection, including WGA, library preparation, and bioinformatic analysis
- Reliable detection of CNVs from trophectoderm (TE) samples, including whole-chromosome and segmental gains/losses ≥10 Mb and mosaicisms ≥30%
- Powered by industry-leading PicoPLEX WGA technology, providing unparalleled reproducibility and coverage uniformity
- Scalable library prep workflow requires about two hours of hands-on time and allows for multiplexing of up to 96 samples
- Broad compatibility with multiple sequencing platforms; validated protocols provided for Illumina® MiSeq® and NextSeq® 500/550
- Intuitive, cloud-based analysis software provided for streamlined processing of sequencing data and reporting of results
- Fully compatible with Opentrons OT-2 instrument, enabling seamless integration into automated liquid handling workflows
More Information
Sequencer Compatibility
Illumina
- MiSeq
- NextSeq 500/550
MGI
- DNBSEQ-G99RS
- DNBSEQ-G400RS
- DNBSEQ-T1+RS
Element
- Aviti
Applications
- Detection of CNVs in gDNA and TE research samples
- Reproductive health research
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Product Components List to determine kit components. Certificates of Analysis and Product Components Lists are located under the Documents tab.
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