NucleoSpin RNA Plus XS—fast, efficient RNA isolation from the smallest samples
The NucleoSpin RNA Plus XS kit is designed to purify RNA from very small amounts of a wide variety of cell and tissue types, as well as from single mammalian cells. This kit includes the NucleoSpin gDNA Removal Column XS, a spin column that quickly and effectively removes genomic DNA without the need for DNase digestion. See our NucleoSpin RNA Plus XS technical note for more information and data.
Overview
- Developed for extra small samples and single cell analysis
- gDNA removal column eliminates the need for time-consuming DNA digestion
- Novel lysis buffer does not contain beta-mercaptoethanol or TCEP
More Information
| Technology | Silica membrane |
| Format | Two columns: XS column for DNA removal XS column for RNA isolation |
| Starting material | Cultured cells (1–105) Human/animal tissue (<5 mg) |
| Typical yield | HeLa cells (105): 0.5–2 μg HeLa cells (101): 0.05–0.2 ng Mouse liver (0.5 μg): 2.5–8 ng Mouse brain (0.5 μg): 0.1–0.5 ng |
| Elution volume | 5–30 µl |
| A260/A280 | 1.9–2.2 |
| Preparation time | 18 min/6 preps |
| Binding capacity | 110 µg |
Applications
- RNA isolation from small amounts of cultured cells, human/animal tissue
- RNA from samples stored in RNAlater
- Purified RNA is suitable for:
- Real-time RT-PCR
- Northern blotting
- Primer extension
- Array technology
- RNase protection assay
- RNA-sequencing
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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Rapid RNA isolation from extra-small samples, including single cells
NucleoSpin RNA Plus XS provides fast, reliable isolation of high-quality RNA from extra-small (XS) amounts of cells and tissues, including single mammalian cells. This kit utilizes a novel lysis buffer that does not contain ß-mercaptoethanol or TCEP, and it includes gDNA removal columns that eliminate the need for time-consuming DNA digestion. The NucleoSpin RNA Plus XS kit yields highly concentrated RNA (in an elution volume of 5–30 µl) that is ready for all typical downstream applications.
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