ARGENT cell signaling regulation kits from ARIAD
Takara Bio is the exclusive provider of iDimerize products—homodimerization and heterodimerization systems and ligands (e.g., AP20187, AP21967) which were previously provided by ARIAD under the brand name ARGENT. The tables below show the iDimerize nomenclature and the equivalent ARGENT products and components.
Kits/Systems
| ARIAD kit | Equivalent Takara Bio system |
|---|---|
| ARGENT Regulated Homodimerization Kit | iDimerize Inducible Homodimer System |
| ARGENT Regulated Heterodimerization Kit | iDimerize Inducible Heterodimer System |
| ARGENT Regulated Secretion/Aggregation Kit | iDimerize Reverse Dimerization System |
| ARGENT Regulated Transcription Plasmid Kit | iDimerize Regulated Transcription System |
Ligands
- The B/B Homodimerizer (AP20187) induces dimerization of two proteins that each contain the DmrB homodimerization domain (see table below explaining domain nomenclature).
- The A/C Heterodimerizer (AP21967) induces dimerization of a protein possessing the DmrA domain and a second protein containing the DmrC domain.
- The D/D Solubilizer (alternative to AP21998) induces dissociation/disaggregation of proteins possessing DmrD domains. DmrD causes automatic self-association of proteins fused to it.
| ARIAD ligand name | Equivalent Takara Bio system |
|---|---|
| AP20187 | B/B Homodimerizer |
| AP21967 | A/C Heterodimerizer |
| AP21998 | D/D Solubilizer (A different molecule which is functionally equivalent to AP21998) |
Dimerization domains
The amino acid sequences of the FV and FV' domains are identical; however, there are significant differences at the nucleotide sequence level which reduce the potential for recombination between the repeating domain within the pC4M-FV2E plasmid (pHom-Mem1). The same is true of the F and F' domains within pC4M-FV2E (pHet-Mem1). Takara Bio does not distinguish between the two when referring to the dimerization domain.
| Domain name in ARIAD kit | Takara Bio domain name | Takara Bio system |
|---|---|---|
| FV | DmrB | iDimerize Inducible Homodimer System |
| FV1 | DmrB | iDimerize Inducible Homodimer System |
| F | DmrA | iDimerize Inducible Heterodimer System |
| F1 | DmrA | iDimerize Inducible Heterodimer System |
| FRB | DmrC | iDimerize Inducible Heterodimer System |
| FM | DmrD | iDimerize Reverse Dimerization System |
Plasmids
pHet-Act1-2 is a close altermative to pC4N2-RHS/ZF3 and pC4N2-RHS3H/ZF3, but is not identical.
| ARIAD plasmid name | Takara Bio plasmid name | Takara Bio system |
|---|---|---|
| pC4-FV1E | pHom-1 | iDimerize Inducible Homodimer System |
| pC4M-FV2E | pHom-Mem1 | iDimerize Inducible Homodimer System |
| pC4EN-F1 | pHet-Nuc1 | iDimerize Inducible Heterodimer System |
| pC4M-F2E | pHet-Mem1 | iDimerize Inducible Heterodimer System |
| pC4-RHE | pHet-1 | iDimerize Inducible Heterodimer System |
| pC4S1-FM4-FCS-hGH | prHom-Sec1 | iDimerize Reverse Dimerization System |
| pC4EN-FM3 | prHom-Nuc1 | iDimerize Reverse Dimerization System |
| pC4EN-FM2E | prHom-1 | iDimerize Reverse Dimerization System |
| pC4N2-RHS/ZF3 | pHet-Act1-2 | iDimerize Regulated Transcription System |
| pC4N2-RHS3H/ZF3 | pHet-Act1-2 | iDimerize Regulated Transcription System |
| pZ12I-PL-2 | pZFHD1-1 | iDimerize Regulated Transcription System |
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