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Home › Products › Antibodies and ELISA › Primary antibodies and ELISAs by research area › Cell adhesion and ECM › Cadherin

Primary antibodies and ELISAs by research area

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Cadherin detection

Cadherins, a family of transmembrane glycoproteins, each 723–747 amino acids long, that function as calcium-dependent adhesion receptors, play an important role in cell-cell interaction, histogenesis, and cellular transformation. The cadherin family includes E- (epithelial), P- (placental), and N- (neural) cadherin, all of which share a common basic structure but have distinct tissue distributions.

Cadherins, a family of transmembrane glycoproteins, each 723–747 amino acids long, that function as calcium-dependent adhesion receptors, play an important role in cell-cell interaction, histogenesis, and cellular transformation. The cadherin family includes E- (epithelial), P- (placental), and N- (neural) cadherin, all of which share a common basic structure but have distinct tissue distributions.

N-cadherin (also known as cadherin 2 (CDH2), CDHN, NCAD, CD325, and CDw325) contains five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. It plays an essential role in gastrulation and is required for establishment of left-right asymmetry. The interaction of N-cadherin with intracellular catenin proteins contributes to learning and memory processes.

E-cadherin (also known as uvomorulin, cell-CAM 120/80, and L-CAM) is found on epithelial cells in a variety of embryonic and adult tissues. Studies indicate that unstable or reduced expression of E-cadherin correlates with cancer progression, specifically in cases of lung, breast, and hepatocellular carcinoma as well as gastric and prostate tumors. A soluble 80-kDa form of E-cadherin, presumed to be a degradation product of the intact 120-kDa form, has been reported as elevated in the biological fluids of some cancer patients when compared against healthy individuals.

ELISAs for cadherin detection

The Human E-cadherin EIA Kit is a 96-well in vitro enzyme assay—a solid phase E-cadherin (CDH1) ELISA that utilizes two mouse monoclonal E-cadherin antibodies, one of which is coated onto the plate, and the other of which is peroxidase-labeled. It is intended for the quantitative determination of soluble human E-cadherin in serum, urine, cell culture supernatant, and other biological fluids.

Antibodies for cadherin detection

Anti-E-cadherin, anti-P-cadherin, and anti-N-cadherin monoclonal antibodies are constructed by fusing immunized host splenocytes with P3-X63-Ag8 myelomas. 

Affinity-purified IgG antibodies that recognize human N-cadherin protein are raised in rabbit using recombinant protein (Cat. # 18571) or synthetic peptide (Cat. # 18573, 18574), and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human N-cadherin protein.

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Cat. # Product Size Price License Quantity Details
M142 Polyclonal Anti-N-cadherin 0.4 mg USD $376.00

Cadherins are transmembrane glycoproteins of 723–747 amino acids that function as Ca2+-dependent adhesion receptors and are responsible for tight intercellular connections. Members of the cadherin family include: E- (epithelial), P- (placental), and N- (neural) cadherin, which share a common basic structure but show distinct patterns of expression in tissues. The specific binding properties of each member controls selective cell-to-cell adhesion. Regulated expression of the members during development implicates involvement in morphogenesis. Cadherins may also be involved with tumor invasion and metastasis. MAb clones originate from relevant hybridoma cells constructed by fusion between splenocytes of immunized hosts and P3-X63-Ag8 myelomas. This polyclonal antibody was purified from serum-free culture supernatant.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Documents Components Image Data
M126 Monoclonal Anti-Human E-cadherin (Clone SHE78-7) 0.1 mg USD $461.00

Cadherins are transmembrane glycoproteins of 723–747 amino acids that function as Ca2+-dependent adhesion receptors and are responsible for tight intercellular connections. Members of the cadherin family include: E- (epithelial), P- (placental), and N- (neural) cadherin, which share a common basic structure but show distinct patterns of expression in tissues. The specific binding properties of each member controls selective cell-to-cell adhesion. Regulated expression of the members during development implicates involvement in morphogenesis. Cadherins may also be involved with tumor invasion and metastasis. MAb clones originate from relevant hybridoma cells constructed by fusion between splenocytes of immunized hosts and P3-X63-Ag8 myelomas. SHE78-7 was purified from ascitic fluid.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Documents Components Image Data
M110 Monoclonal Anti-chicken N-Cadherin (Clone NCD-2) 0.1 mg USD $461.00

Cadherins are transmembrane glycoproteins of 723–747 amino acids that function as Ca2+-dependent adhesion receptors and are responsible for tight intercellular connections. Members of the cadherin family include: E- (epithelial), P- (placental), and N- (neural) cadherin, which share a common basic structure but show distinct patterns of expression in tissues. The specific binding properties of each member controls selective cell-to-cell adhesion. Regulated expression of the members during development implicates involvement in morphogenesis. Cadherins may also be involved with tumor invasion and metastasis. MAb clones originate from relevant hybridoma cells constructed by fusion between splenocytes of immunized hosts and P3-X63-Ag8 myelomas. NCD-2 was purified from serum-free culture supernatant.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Documents Components Image Data
M109 Monoclonal Anti-mouse P-cadherin (Clone PCD-1 ) 0.1 mg USD $461.00

Cadherins are transmembrane glycoproteins of 723–747 amino acids that function as Ca2+-dependent adhesion receptors and are responsible for tight intercellular connections. Members of the cadherin family include: E- (epithelial), P- (placental), and N- (neural) cadherin, which share a common basic structure but show distinct patterns of expression in tissues. The specific binding properties of each member controls selective cell-to-cell adhesion. Regulated expression of the members during development implicates involvement in morphogenesis. Cadherins may also be involved with tumor invasion and metastasis. MAb clones originate from relevant hybridoma cells constructed by fusion between splenocytes of immunized hosts and P3-X63-Ag8 myelomas. PCD-1 was purified from serum-free culture supernatant.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Documents Components Image Data
M108 Monoclonal Anti-mouse E-cadherin (Clone ECCD-2) 0.1 mg USD $470.00

Cadherins are transmembrane glycoproteins of 723–747 amino acids that function as Ca2+-dependent adhesion receptors and are responsible for tight intercellular connections. Members of the cadherin family include: E- (epithelial), P- (placental), and N- (neural) cadherin, which share a common basic structure but show distinct patterns of expression in tissues. The specific binding properties of each member controls selective cell-to-cell adhesion. Regulated expression of the members during development implicates involvement in morphogenesis. Cadherins may also be involved with tumor invasion and metastasis. MAb clones originate from relevant hybridoma cells constructed by fusion between splenocytes of immunized hosts and P3-X63-Ag8 myelomas. ECCD-2 was purified from serum-free culture supernatant.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Documents Components Image Data
M107 Monoclonal Anti-mouse E-cadherin (Clone ECCD-1) 0.1 mg USD $461.00

Cadherins are transmembrane glycoproteins of 723–747 amino acids that function as Ca2+-dependent adhesion receptors and are responsible for tight intercellular connections. Members of the cadherin family include: E- (epithelial), P- (placental), and N- (neural) cadherin, which share a common basic structure but show distinct patterns of expression in tissues. The specific binding properties of each member controls selective cell-to-cell adhesion. Regulated expression of the members during development implicates involvement in morphogenesis. Cadherins may also be involved with tumor invasion and metastasis. MAb clones originate from relevant hybridoma cells constructed by fusion between splenocytes of immunized hosts and P3-X63-Ag8 myelomas. ECCD-1 was purified from serum-free culture supernatant.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Documents Components Image Data
M106 Monoclonal Anti-Human E-cadherin (Clone HECD-1) 0.1 mg USD $461.00

Cadherins are transmembrane glycoproteins of 723–747 amino acids that function as Ca2+-dependent adhesion receptors and are responsible for tight intercellular connections. Members of the cadherin family include: E- (epithelial), P- (placental), and N- (neural) cadherin, which share a common basic structure but show distinct patterns of expression in tissues. The specific binding properties of each member controls selective cell-to-cell adhesion. Regulated expression of the members during development implicates involvement in morphogenesis. Cadherins may also be involved with tumor invasion and metastasis. MAb clones originate from relevant hybridoma cells constructed by fusion between splenocytes of immunized hosts and P3-X63-Ag8 myelomas. HECD-1 was purified from ascitic fluid.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Documents Components Image Data Resources

Overview

Antigen
Cat. #
Application
Species
(Clone) and source
Cross-reactivity
E-cadherin M106 IHC, WB,
Cell-cell contact inhibition assay		 Human (HECD-1)
Mouse IgG1MoAb		 Cross-reacts with guinea pig E-cadherin

Does not cross-react with bovine, dog, rat, or chicken E-cadherin
E-cadherin M107 Cell-cell contact inhibition assay Mouse (ECCD-1)
Rat IgG2b MoAb		 Does not cross-react with human, bovine, dog, or chicken E-cadherin
E-cadherin M108 IHC, WB Mouse (ECCD-2)
Rat IgG2a MoAb		 Cross-reacts with human and dog E-cadherin
E-cadherin M126 IHC, WB,
Cell-cell contact inhibition assay		 Human (SHE78-7)
Mouse IgG2a MoAb		 Does not cross-react with rat E-cadherin
P-cadherin M109 IHC, WB,
Cell-cell contact inhibition assay		 Mouse (PCD-1)
Rat IgG2a MoAb		 Does not cross-react with human or chicken P-cadherin
P-cadherin M127 IHC, WB,
Cell-cell contact inhibition assay		 Human (NCC-CAD-299)
Mouse IgG1 MoAb		 n/a
N-cadherin M110 IHC, WB,
Cell-cell contact inhibition assay		 Chicken (NCD-2)
Rat IgG2a MoAb		 Cross-reacts with xenopus N-cadherin

Does not cross-react with human or mouse N-cadherin
N-cadherin
(808–827) conjugated with KLH		 M142* IHC, WB Human (n/a)
Rabbit PoAb		 Cross-reacts with bovine, mouse, and chicken N-cadherin

Does not react with human E- or P-cadherin

*Product availability varies by region.

More Information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.

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