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Home › Products › Antibodies and ELISA › Primary antibodies and ELISAs by research area › Stem cell research antibodies › Neural progenitor cell antibodies

Primary antibodies and ELISAs by research area

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Neural progenitor cell antibodies: Bf1, Crx, Emx1, Irx3, L7/Pcp2, Otp, Otx2, Rx, and Six3

Neural progenitor cells express characteristic protein biomarkers, and antibodies to these biomarkers allow analysis of cell differentiation during embryonic development and organogenesis. These antibodies are of particular use for studies in the field of regenerative medicine, may be used as neurogenesis differentiation markers with ES or iPS cells, and are suitable for immunohistochemistry on fixed tissue and Western blotting.

Neural progenitor cells express characteristic protein biomarkers, and antibodies to these biomarkers allow analysis of cell differentiation during embryonic development and organogenesis. These antibodies are of particular use for studies in the field of regenerative medicine, may be used as neurogenesis differentiation markers with ES or iPS cells, and are suitable for immunohistochemistry on fixed tissue and Western blotting.

L7 antibodies allow detection of Purkinje cells, which are the output neurons of the cerebellar cortex. Otp antibodies can be used to identify differentiating hypothalamic neuroendocrine cells. Antibodies to Emx1 allow detection of this cerebral cortical marker during early embryogenesis. Six3 antibodies have been used to study generation of rostral hypothalamic-like progenitors from mouse ES cell-derived neuroectodermal cells. Otx2 antibodies have been used to study differentiation of retinal progenitors in embryonic neural retina and induced ES cells in culture. The transcription factor detected by anti-Brain Factor 1 (Bf1) antibodies localizes to cerebral nerve precursor cells in a rostral region called the telencephalon. Rx antibodies detect a transcription factor critical for protein expression in retinal progenitor cells. Antibodies to Iroquois Homeobox Protein 3 (Irx3) can be used to study early development of the central nervous system and the caudal nerves. Detection of the photoreceptor-specific transcription factor Cone-rod homeobox protein (Crx) with anti-Crx antibodies enables study of the development and differentiation of retinal photoreceptor cells and the pineal gland.

These polyclonal antibodies were developed in the laboratory of Yoshiki Sasai, MD, PhD, Center for Developmental Biology (RIKEN).

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Cat. # Product Size License Quantity Details
M231 Anti-Human Crx, Polyclonal 0.2 mg USD $489.00

Antibody to neural progenitor cells; detects neurogenesis biomarkers. Use for embryogenesis and stem cell research. This is a rabbit polyclonal antibody raised against two peptide fragments of Human Crx (Cone-rod homeobox protein; a transcription factor that is specifically expressed in photoreceptors and pinealocytes and is important for development and functional homeostasis of cone cells and rod cells forming the retinal cells) conjugated with KLH.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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M230 Anti-Mouse Irx3, Polyclonal 0.2 mg USD $495.00

Antibody to neural progenitor cells; detects neurogenesis biomarkers. Use for embryogenesis and stem cell research. This is a rabbit polyclonal antibody raised against C-terminal region peptide of mouse Irx3 (Iroquois related homeobox 3) [CSALE VEKKL LKTAF QPVPR RPQNH LDAAL VLSAL SSS] conjugated with KLH. Irx 3 is a transcription factor that is localized in the caudal nerve and expressed in the neural plate during the early development of the central nervous system.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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M229 Anti-Human/Mouse Rx, Polyclonal (Guinea Pig) 0.2 mg USD $489.00

Antibody to neural progenitor cells; detects neurogenesis biomarkers. Use for embryogenesis and stem cell research. This is a guinea pig polyclonal antibody raised against three peptide fragments of Rx (Retinal homeobox protein; a homeobox transcription factor that functions in eye development and is expressed early in the eye primordi,) conjugated with KLH.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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M228 Anti-Mouse Rx, Polyclonal 0.2 mg USD $489.00

Antibody to neural progenitor cells; detects neurogenesis biomarkers. Use for embryogenesis and stem cell research. This is a rabbit polyclonal antibody raised against three peptide fragments of Rx (Retinal homeobox protein; a homeobox transcription factor that functions in eye development and is expressed early in the eye primordi,) conjugated with KLH.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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M227 Anti-Human/Mouse Bf1, Polyclonal 0.2 mg USD $489.00

Antibody to neural progenitor cells; detects neurogenesis biomarkers. Use for embryogenesis and stem cell research. This is a rabbit polyclonal antibody raised against C-terminal region peptide of human/mouse Brain factor 1 (Transcription Factor BF-1/forkhead box protein G1/FOXG1B) [SLPSF TTGLS GGLSD YFTHQ NQGSS SNPLI H] conjugated with bovine thyroglobulin. Brain factor 1 is a transcription factor that is localized in the neural progenitor cells for the cerebrum. It is responsible for the development of the telencephalon.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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M202 Polyclonal Antibody to Human L7/Pcp2 0.2 mg USD $489.00

Antibody to neural progenitor cells; detects neurogenesis biomarkers. Use for embryogenesis and stem cell research. This is a rabbit polyclonal antibody raised against C-terminal region peptide [TALGF RRNSS PQPPT QAP] of human L7/Pcp2 (a marker of the purkinje progenitor cells in brain and nervous system) conjugated with KLH.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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M198 Polyclonal Antibody to Mouse Otx2 100 uL USD $489.00

Antibody to neural progenitor cells; detects neurogenesis biomarkers. Use for embryogenesis and stem cell research. This is a rabbit polyclonal antibody raised against C-terminal region peptide [CGSYL TPMHH QLPGP GATLS PMGTN] of mouse Otx2 [Orthdenticle homeobox 2; a marker of the most upstream transcription factor that controls the differentiation of the forebrain and the retinal photoreceptor cells (cone cells and rod cells) in embryonic development] conjugated with KLH.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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M196 Polyclonal Antibody to Mouse Emx1 100 uL USD $489.00

Antibody to neural progenitor cells; detects neurogenesis biomarkers. Use for embryogenesis and stem cell research. This is a guinea pig polyclonal antibody raised against C-terminal region peptide [ESEQK KKGSH HINRW RIATK QANGE DIDVT SND] of mouse Emx 1 (Empty spiracles homeobox 1; marker of embryonic development in cerebral cortex neurons) conjugated with KLH.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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M195 Polyclonal Antibody to Mouse Otp 100 uL USD $489.00

Antibody to neural progenitor cells; detects neurogenesis biomarkers. Use for embryogenesis and stem cell research. Otp is a guinea pig polyclonal antibody raised against C-terminal region peptide [LRRKA LEHTV SMSFT] of mouse Otp (homeobox protein Orthopedia; a marker of the hindbrain and hypothalamic neurons during embryonic development ) conjugated with KLH.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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M194 Polyclonal Antibody to Mouse L7/Pcp2 100 uL USD $489.00

Antibody to neural progenitor cells; detects neurogenesis biomarkers. Use for embryogenesis and stem cell research. L7/Pcp2 is a rabbit polyclonal antibody raised against C-terminal region peptide [AALSF RRNSS PQPQT QAP] of mouse L7/Pcp2 (a marker of the purkinje progenitor cells in brain and nervous system) conjugated with KLH.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

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Overview

Neural progenitor cells: antibody specifications

  Cell type detected Antigen Species Specificity Cat. #
Bf1

 Cerebral neural progenitor cells in the telencephalon

 C‑terminal peptide of human/mouse Bf1 conjugated with bovine thyroglobulin

 Human
Mouse

 C‑terminal region of human and mouse Bf1

 M227
Crx

 Retinal photoreceptor cells (cone and rod cells) during embryonic development

 KLH‑conjugated peptide fragments of human Crx

 Human

 Human Crx

 M231
Emx1

 Cerebral cortex neurons during embryonic development

 KLH‑conjugated peptide of mouse Emx1

 Mouse

 C‑terminal region of mouse Emx1

 M196
Irx3

 Neural plate progenitor cells involved in caudal nerve development

KLH‑conjugated peptide from the C‑terminal region of mouse Irx3

 Mouse

 Mouse Irx3

 M230
L7/Pcp2

 Purkinje progenitor cells

 KLH‑conjugated peptide from the C‑terminal region of L7/Pcp2

 Mouse

 C‑terminal region of mouse L7/Pcp2

 M194
Human

 C‑terminal region of mouse L7/Pcp2; Reacts with human & mouse L7/Pcp2

 M202
Otp

 Hindbrain and hypothalamic neurons during embryonic development

 KLH‑conjugated peptide from the C‑terminal region of mouse Otp

 Mouse

 C‑terminal region of mouse Otp

 M195
Otx2

 Retinal photoreceptor cells during embryonic development

 KLH‑conjugated peptide from the C‑terminal region of Otx2

 Mouse

 C‑terminal region of mouse Otx2

 M198
Human

 C‑terminal region of human Otx2

 M199
Rx

 Retinal progenitor cells

 KLH‑conjugated peptide fragments of Rx

 Mouse

 Mouse Rx

 M228
Human
Mouse

 Human & mouse Rx

 M229
Six3

 Rostral brain progenitors; forebrain and retina, early embryonic and CNS development

 KLH‑conjugated peptide from the C‑terminal region of mouse Six3

 Mouse

 C‑terminal region of mouse Six3

 M197

More Information

Applications

  •     Immunohistochemical staining on fixed tissue

  •     Western blotting under reducing conditions (Cat. # M196, M197, M228, M229, M230, M231)

Additional product information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.

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