Calpain inhibitor: Calpastatin protease inhibitor

Calpastatin is an endogenous protease inhibitor that acts specifically on calpain (a calcium-dependent cysteine protease). It contains four repetitive calpain inhibition sequences spanning 120 to 140 amino acid residues (domains I, II, and IV) and an N-terminal non-homologous sequence (domain L). The product consists of highly purified recombinant human calpastatin domain I.

Cat. #	Product	Size	Price	License	Quantity	Details
7316	Calpastatin	3 mg	USD $310.00
Calpastatin is an endogenous protease inhibitor that acts specifically on calpain (a calcium-dependent cysteine protease). It consists of four repetitive sequences comprising of 120 to 140 amino acid residues, and an N-terminal non-homologous sequence(L). This product is obtained from highly purified domain I of human calpastatin, comprising of 135 amino acids (MW 14,000), which is produced by genetic recombination technique. Notice to purchaser Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval. Documents Components Image Data Back 7316: Calpastatin

More Information

Applications

Calpain protease inhibition

Source

Recombinant Human Calpastatin Domain I

Storage

–20°C

Properties

Molecular weight: 14 kDa
Peptide length: 137 aa
Typical activity: 50 nM of calpastatin domain I completely inhibits the activity of 7.5 µg/ml calpain I. 15 nM of calpastatin domain I inhibits 50% of the activity of 7.5 µg/ml calpain I.

Form

Lyophilized white powder

Product citations

Asada, K. et al. cDNA cloning of human calpastatin: sequence homology among human, pig, and rabbit calpastatins. J. Enz. Inhib. 3:49 (1989).

Kanaki, R. and Murachi, T. Physiological significance of the calpain-calpastatin system. Protein, Nucleic Acid and Enzyme 32:116 (Japanese Journal) (1987).

Uemori, T. et al. Characterization of a functional domain of human calpastatin. Biochem. Biophys. Res. Comm. 166:1485 (1990).

Additional product information

Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.

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