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Custom services

Gene and cell therapy manufacturing services

Takara Bio offers high-quality, innovative tools and services to help research groups accelerate translational and clinical discoveries. As a contract manufacturing organization (CMO) that provides a variety of manufacturing services, Takara Bio is committed to understanding and meeting the quality needs and expectations of our customers. Please click here to read our Quality Statement.

We foster an environment of collaboration and innovation between our team members and the research community, providing custom solutions that address any stage of the gene and cell therapy development process. Top researchers, research groups, and companies collaborate with us on a variety of projects.

One ongoing project is the development of a quality-control system for maintaining a large stock of induced pluripotent stem (iPS) cells needed for clinical trials. Kyoto University's Center for iPS Cell Research and Application (CiRA), headed by Shinya Yamanaka, is collaborating with Takara Bio to ensure that the needs of iPS cell clinical research and therapeutic use are met.

In order to create high-quality iPS cells, we started working with Takara Bio in January [2017] to create a quality-control system."

—Shinya Yamanaka, KYOTO UNIVERSITY

Kusashio, T. Nobel laureate has high hopes for donor iPS cells. Nikkei Asian Rev. (2017).

Why Takara Bio? Gene therapy pipeline Reagents and services

Why Takara Bio?  

Takara Bio offers comprehensive and seamless manufacturing and quality-testing services for cellular and gene therapy products.

  • CMO services include viral vector production, T-cell processing, human embryonic stem (hES) cell line derivation, quality testing, and cell banking
  • State-of-the-art GMP manufacturing sites in Japan and Europe enable the production of safe, dependable products under stringent manufacturing conditions
  • Expert assistance on navigating regulations and custom industrial applications simplifies the workflow and provides peace of mind from start to finish

Gene therapy pipeline  

For over 20 years, Takara Bio has developed novel products with important gene therapy applications. In 1995, Takara Bio and Indiana University developed the RetroNectin method, which involves using a plate-coating substance to increase the physical interactions of cells and viruses, greatly increasing transduction efficiency.

Since that time, we have developed additional ways of using the RetroNectin method and viral vector technology for new therapeutic applications, such as in boosting naïve-like T-cell expansion for CAR-T therapy. RetroNectin reagent, now available as a GMP-grade version, has been used in over 60 clinical studies around the world.

Clinical trials for gene therapy projects

Products manufactured by Takara Bio but developed independently by various organizations, as well as products jointly developed with and manufactured by Takara Bio, are being tested in ongoing clinical trials, with the goals of steady progress and commercialization in the near future. To find out more about Takara Bio’s clinical trials, click here.

Reagents and services  

Long history as a research reagent supplier

Since 1979, Takara Bio has been continuously developing molecular and cellular research reagents for the life science research community. Now, we offer a unique combination of GMP-grade products and gene analysis services to meet your manufacturing and quality-control needs.

GMP-grade products

Our T-cell immunotherapy products are well-integrated into our T-cell immunotherapy manufacturing service. RetroNectin reagent, a recombinant human fibronectin fragment, is widely used to enhance lentiviral- and retroviral-mediated gene transduction. To meet the clinical research community's needs for a reagent suitable for ex vivo clinical applications, we developed RetroNectin GMP Grade. As T-cell expansion for clinical applications requires additional products, we have expanded our product line to include GMP-grade anti-CD3 monoclonal antibody, T-cell culture media (research grade), and CultiLife culture bags.

Takara Bio also offers GMP-grade stem cell research products. Cellartis DEF-CS 500 Xeno-Free GMP Grade Basal Medium is a proprietary human pluripotent stem cell maintenance medium that complies with the highest conditions of stringency, and is completely free of all animal and human components to avoid introducing any pathogens or immunogens to patients.

Gene analysis services

Leveraging our extensive gene analysis techniques and expertise, Takara Bio provides contract research services for gene analysis. We provide advanced genetic engineering research support services and equipment used in techniques such as next-generation sequencing and genome editing. Takara Bio is certified by the College of American Pathologists’ Laboratory Accreditation Program (CAP-LAP) for Molecular Pathology, Next Generation Sequencing.

Please submit inquiries using the form on the left. If you are on a mobile device, click on the hamburger icon () on the top left of your screen, then scroll down to access the form.


Services

Takara Bio offers a comprehensive set of manufacturing and quality-testing services for gene and cell therapy products.

Facilities

Takara Bio's award-winning, integrated facilities do more than streamline your workflow.

Our process

Takara Bio's integrated management executes your clinical project efficiently and carefully.

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Takara Bio USA, Inc. provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, TBUSA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

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The rapid spread of severe infections by viruses such as SARS-CoV-2, HIV, H1N1, Ebola, and Zika has highlighted the critical need for the rapid development of vaccines against previously unknown pathogens to deal with pandemics such as COVID-19 effectively.

Takara Bio is proud to be on the front line in the fight to defeat the novel coronavirus by enabling innovative vaccine development. This section discusses tools and techniques to overcome the challenges faced during the vaccine development process.

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Capturem Trypsin for a rapid, efficient mass spectometry workflow at room temperature.

Speed up your mass spec workflow

Capturem Trypsin provides rapid, efficient, and complete digestion of protein samples, allowing an uninterrupted mass spectometry workflow at room temperature for downstream protein analysis. This product utilizes our novel Capturem technology in a spin column format with membrane-immobilized trypsin. Capturem Trypsin Columns may be used to completely digest protein samples in less than a minute with digestion efficiencies (protein coverage) comparable to or better than those obtained using in-solution trypsin digestion.

Capturem trypsin technology

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Takara Bio USA, Inc. provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, TBUSA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES (EXCEPT AS SPECIFICALLY NOTED).

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