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Educational activity

Celebrate National DNA Day!

Please join us in celebrating National DNA Day on April 25. You can help students and kids in your life understand the importance of DNA by following scientists at Takara Bio as they demonstrate how to extract DNA from strawberries. The lesson plan based on this demonstration guides mentors to teach about DNA and genomic research, starting with having students extract DNA on their own.

Overview

The lesson plan is organized around the activity of extracting DNA from strawberries, as illustrated in the That's Good Science National DNA Day 2022 video on the Takara Bio website (above).

The lesson helps students visualize DNA and learn about careers in biotechnology. 

The science behind key concepts and practical applications are explained using the video, resource links, and biographies.

The full lesson should take two class periods. The DNA extraction activity takes one period. Additional discussion can be held a day before the hands-on activity. Choose from several activities under Additional Resources and customize for your grade level.

Academic standards

This lesson can be used to teach NGSS Core Ideas LS1.A (Structure and function) and LS3.A (Heredity).

Lesson plan Featured scientists Additional resources

Lesson plan  

Objectives

  • Students will identify where DNA is located in cells
  • Students will get the DNA out of cells (called DNA extraction)
  • Students will discuss real-world examples of DNA used to understand heredity
  • Students will learn about careers where professionals work with DNA technology

Background information

National DNA Day, celebrated on April 25 each year, commemorates the successful completion of the Human Genome Project in 2003 and the discovery of DNA's double helix in 1953. The goal of National DNA Day is to offer students, educators, and the public an opportunity to learn about the DNA molecule and genomic research.

Getting ready

Materials (per student)
  • 1–3 fresh or frozen (and defrosted) strawberries
  • 1 quart-sized plastic Ziploc bag
  • A teaspoon (students can share a measuring spoon set)
  • A ¼ cup measuring cup
  • A pyrex or other cup for measuring water
  • A glass cup
  • Paper coffee filter
  • Rubber band
  • 1 wooden stir stick
  • Optional: additional plastic bag or small container for storing the extracted DNA

DNA extraction liquid (enough for 2 students)

  • ½ cup water
  • 1 teaspoon table salt
  • 2 teaspoons dish soap
Mentor preparation
  • Read the lesson plan all the way through
  • Practice extracting DNA from strawberries in order to guide students in the class
Classroom preparation
  • Set up stations for DNA extraction with required materials

In the classroom

Warm-up discussion—Day 1 (50 minutes)
  1. Explore the differences between animal, plant, and bacterial cells using an online interactive tool. Have students locate where the DNA lives in each type of cell. (20 minutes)
  2. Brainstorm (15 minutes)
    1. How are we going to get the DNA out of the cells?
      • Write down words they use to describe the process. Examples: smash, pop, melt, explode, etc.
      • Explain that there is a process scientists call DNA extraction, which is used to get DNA out of cells. We are going to extract DNA from strawberries.
    2. What does the DNA in strawberries look like?
      • Write down their answers on the board so they can compare with actual results. Examples: color, consistency, shape.
    3. How much DNA can be extracted from 1 strawberry? From 3 strawberries?
      • Write down their answers again. Examples: an eraser, a quarter, a fingernail, a gummy worm, a gummy bear, an M&M, a teaspoon. Bring an actual measuring spoon set.
  3. Show the video on DNA extraction from strawberries and discuss, making sure everyone understands the protocol (10 minutes)
  4. Review one-page strawberry DNA extraction protocol (5 minutes)
Hands-on activity—Day 2 (50 minutes):
  1. Review one-page strawberry DNA extraction protocol. Print this protocol to use as a visual resource while performing the extraction. (5 minutes)
  2. Perform the extraction (20 minutes) using the recipe:
    1. Crush the strawberries
    2. Make the DNA extraction liquid (for 2!)
      • Measure ½ cup water
      • Add 1 teaspoon salt
      • Add 2 teaspoons dish soap
      • Stir well without causing bubbles
    3. Add ¼ cup liquid to the strawberries
    4. Mix gently
    5. Filter the mixture
    6. Mark the cup
      • Draw a line at the top of the filtered strawberry mixture
      • Draw a second line at double the height (for the rubbing alcohol)
    7. Add rubbing alcohol to the second line
    8. Use a stir stick to pull out the DNA!
  3. Discuss what can be done with DNA once it’s extracted (in the video, Tom mentioned forensic analysis, genetic analysis, and determining ancestry). (5 minutes)
  4. Discuss careers in biology that use DNA. Read profiles (below) of the scientists at Takara Bio who performed the DNA extraction. (10 minutes)

Featured scientists  

Lily Lee

Lily Lee is a Research Associate IV at Takara Bio USA. In 1997, she started working at Takara Bio USA creating oligonucleotides, small pieces of DNA for use in research. She then started developing new products for researchers that detect interesting things in DNA, like the amount of a specific gene. For the last 16 years, she has been working on research and development of new products for putting new DNA into immune cells, editing DNA in cells, and using harmless viruses to put new DNA into cells. Lily says, "I am grateful that I get to acquire new skills and work on new technologies which allowed me to contribute to so many great products but the best part of my career is working with all the friendly and talented people here." 

Headshot

Tom Quinn

Tom Quinn is a group leader at Takara Bio USA. In 1998, Tom started working at Takara Bio USA developing tools that let researchers use harmless viruses to put new DNA into cells. Some of these viruses come from families called adenoviruses, retroviruses, lentiviruses, and adeno-associated viruses. These virus tools help researchers study both inherited and acquired diseases. Putting therapeutic DNA into cells can fix the mutations that cause the disease. Tom says, "I find this work to be very rewarding because the tools my team develop can help researchers and healthcare professionals figure out how diseases work and develop treatments."

Headshot

Additional resources  

Topics to explore with students grades 6-9:
  1. What is heredity?
    • https://teach.genetics.utah.edu/content/heredity/
    • A comprehensive set of resources on heredity: https://sciencetrek.org/sciencetrek/topics/heredity/teachers.cfm
    • https://learn.genetics.utah.edu/content/basics/
  2. How are traits passed to you from your parents?
    • California state stem cell curriculum, NGSS-aligned module: https://www.cirm.ca.gov/our-progress/natural-and-vitro-fertilization-create-embryonic-stem-cells#overlay-context=our-progress/ngss-cirm-curriculum
    • PowerPoint presentations explaining stem cell biology: https://www.cirm.ca.gov/our-progress/introductory-lessons-stem-cells-and-regenerative-medicine
    • Play Doh embryonic development activity: https://www.cirm.ca.gov/sites/default/files/files/about_stemcells/Unit_1_Appendix_C_NG_LB_0.pdf
    • Complete high-school level stem cell curriculum: https://www.cirm.ca.gov/our-progress/model-stem-cell-curriculum-overview
  3. Where does the DNA occur in animal, plant, and bacterial cells?
    • Online interactive visualization of parts of cells: https://www.unlockinglifescode.org/resource/hudsonalpha-icell
  4. Why is DNA important in passing along traits?
    • Activity (intermediate): https://teach.genetics.utah.edu/content/heredity/#item8
  5. What does DNA look like?
    • Takara Bio lesson: DNA extraction from strawberries
  6. What can you do with DNA?
    • Send a sample of your DNA for genetic testing to discover long-lost relatives, hints about ancestry, or genetic risk factors for a variety of health conditions. You can also test your dog's DNA to see what breeds it is.
    • Use forensics to identify people at a crime scene
    • Change the DNA to make it produce a different form, like in glowing fish.
  7. What jobs let you work with DNA technology?
    • Careers in genomics: https://www.genome.gov/careers-in-genomics
    • Featured Takara Bio scientists

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