Tet-One System Mechanism — The Tet-On 3G transactivator protein is expressed constitutively from the human PGK promoter (PPGK) but is unable to bind to the TRE3G promoter (PTRE3G) in the absence of doxycycline (Dox)

Seven out of eight Tet-One clones show more than 1,000-fold induction of expression

The Tet-One system is highly sensitive to low levels of doxycycline (Dox)

Lenti-X Tet-One Vector maps

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