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Home › Services & Support › Stem cell services › Research-grade stem cell services › Directed differentiation to definitive endoderm cells

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Cellartis Human Pluripotent Stem Cell Services

Directed differentiation to definitive endoderm cells

We have over 15 years of experience differentiating pluripotent cells along the endodermal lineage. Using a proprietary protocol that mimics normal embryonic development, your pluripotent cells will be differentiated into high-quality definitive endoderm (DE) cells.

For more information about our services, please submit the service inquiry form below.

Overview Convenient options Deliverables/lead time QC testing Project initiation

Overview  

With the Cellartis directed differentiation to DE cells service, we deliver high-quality, custom DE cells derived from your human ES or iPS cells. As an alternative to providing your own cells, you may request Cellartis sourcing or reprogramming services.

Our differentiation protocols start with thawing and adapting your pluripotent cells to the Cellartis DEF-CS 500 Culture System, which maintains cells in a highly pluripotent and homogeneous state. After adaptation, cells are expanded to generate a Seed Bank. The pluripotent cells are then differentiated into definitive endoderm cells, banked, and characterized.


Thawing of your ES or iPS cells and adaptation to the DEF-CS system
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Expansion of the cells in the DEF-CS system and generation of a Seed Bank
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Differentiation into definitive endoderm cells and banking
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Characterization of the banked, final cell product (QC testing included)

Convenient options  

Our standard service includes delivery of 30 vials of human iPS- or ES cell-derived definitive endoderm cells. To meet your requirements for early evaluation, we can also provide a small-scale delivery service of 5 vials.

Deliverables/lead time  

Service Cat. # Deliverables Lead time
Cellartis hiPS Directed Differentiation to DE Cells Service (5 vials) Y60212
  • Project report
  • 5 vials of DE cells (6 million viable cells per vial)

Approx. 16 weeks

Cellartis hES Directed Differentiation to DE Cells Service (5 vials) Y60213
  • Project report
  • 5 vials of DE cells (6 million viable cells per vial)

Approx. 16 weeks

Cellartis hiPS Directed Differentiation to DE Cells Service (30 vials) Y60210
  • Project report
  • 30 vials of DE cells (6 million viable cells per vial)

Approx. 16 weeks

Cellartis hES Directed Differentiation to DE Cells Service (30 vials) Y60211
  • Project report
  • 30 vials of DE cells (6 million viable cells per vial)

Approx. 16 weeks

Cellartis hiPS Directed Differentiation to DE Cells Service (Add-On, 30 vials)

(available after initial purchase of 5- or 30-vial option)

Y60214

  • Project report
  • Add-On, 30 vials of DE cells (6 million viable cells per vial)

Approx. 14 weeks

Cellartis hES Directed Differentiation to DE Cells Service (Add-on, 30 vials)

(available after initial purchase of 5- or 30-vial option)

Y60215

  • Project report
  • Add-On, 30 vials of DE cells (6 million viable cells per vial)

Approx. 14 weeks

QC testing  

Included with definitive endoderm directed differentiation services:

  • Visual inspection of DE cell morphology
  • Viability (>6 million viable cells per vial)
  • Immunocytochemistry to verify the definitive endoderm phenotype: Sox-17 (+), Oct-4 (-)
  • Sterility testing (including Mycoplasma)

Project initiation  

Successful differentiation depends on the quality of the starting material; a homogeneous, undifferentiated stem cell population is ideal. To get started, we will need 5 vials (2.5 million cells per vial) of customer-provided hiPS or hES cells, with relevant information, including name of the donor cell line, culture conditions, and cell density upon freezing. Your cells will be adapted to the DEF-CS system, and then the differentiation protocol can begin.

For safety and QC purposes, we can only work with human samples that are free of human pathogens and that have passed a sterility test. We require documentation proving that all samples shipped to us are sterile and pathogen-free. In the absence of documentation, testing for pathogens (Cat. # Y60301) and sterility (Cat. # Y60302) will be performed via a third-party service prior to the initiation of Cellartis services. Please note that safety and sterility testing will incur additional lead time and costs.

  1. Submit the service inquiry form below.
  2. We contact you to go over your project requirements and provide a quote.
  3. Place your order and ship us the necessary cells and documentation to initiate the service.
  4. We perform the agreed-upon service according to the designated lead times.
  5. We provide you with the agreed-upon deliverables.

    Note: Takara Bio Europe, AB (TBEAB) will perform the differentiation service only one time per purchase. Each purchase of the differentiation service includes protocol optimization to determine whether or not successful differentiation of the Customer’s iPS or ES cell line can be achieved. If a successful differentiation cannot be achieved after the performance of the protocol optimization, the differentiation service will be terminated and neither TBUSA nor TBEAB will have any further obligation, including additional attempts of the differentiation service. If additional work is required, TBUSA will discuss such work, pricing, and lead time with the customer.

Definitive endoderm differentiation services

Cat. # Product Size License Quantity Details
Y60210 Cellartis® hiPS Directed Differentiation to DE Cells Service (30 vials) Each Inquire for Quotation

License Statement

ID Number  
L69 This product is covered by one or more claims of the issued patents and pending patent applications: U.S. Patent Nos. 8,048,999, 8,058,065, 8,129,187, 8,211,697, 8,257,941, 8,278,104, 8,530,238, 8,900,871, 8,927,277, 8,951,801, 9,213,999, 9,404,124, 9,499,797, 9,677,141, 9,714,433, and 9,938,585 and foreign counterparts thereof, including their divisions, continuations, extensions, substitutions, and those claiming priority therefrom or those claiming the same priorities therein.

This custom service is provided by Takara Bio Inc. and/or its affiliate(s) based on a patent license from iPS Academia Japan, Inc. No express or implied license is granted to the purchaser. "Product" means the customized differentiated cells manufactured and sold by Takara Bio Inc.

"Internal research purpose" means the use of this Product as a tool of internal research for the sole benefit of the purchaser or purchaser's contract research customer, (including screening of compounds, antibodies, proteins, peptides and others in developing pharmaceuticals (including diagnostic agents) for human and/or animal use), provided, however, that the following activities using this Product are strictly prohibited and expressly excluded from Internal research purposes:

With the exemption for academic and non-commercial clinical research done by non-profit institutions;

1) Administration of this Product to humans.

2) Use of this Product for the diagnostic testing, prevention, or treatment of human and/or animal diseases.

3) Use of this Product in studies involving administration to humans for cell therapy, regenerative medicine etc.

Purchaser may use this Product for its own Internal research purposes.

Purchaser shall not use the Products for its commercial purposes.

Notwithstanding the foregoing, the purchaser of this Product may provide third parties with contract research services by using this Product only for such third party's Internal research purposes.
C013 This service is performed by Takara Bio Inc. and/or its affiliate(s) (“Takara”) under a license from ViaCyte Inc. (“ViaCyte”). This product is covered by one or more claims of patents owned by ViaCyte, including WO2005063971, WO2006017134, WO2006071911, WO2005116073 and WO2006016999, and their foreign counterparts. The use of the deliverables is strictly limited to purchaser's own internal research. Purchaser has no right to use the deliverables or their components in humans for any purposes including but not limited to diagnostics, therapeutics, or clinical trials. Purchaser has no right to resell or transfer the deliverables to a third party regardless of whether or not compensation is received. Purchasers wishing to use the deliverables for purposes other than internal research use should contact Takara. No express or implied license is granted to the purchaser.
*

With Cellartis directed differentiation services, we will deliver high-quality, custom hepatocytes or definitive endoderm cells derived from your human ES or iPS cells.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Y60211 Cellartis® hES Directed Differentiation to DE Cells Service (30 vials) Each Inquire for Quotation

License Statement

ID Number  
C013 This service is performed by Takara Bio Inc. and/or its affiliate(s) (“Takara”) under a license from ViaCyte Inc. (“ViaCyte”). This product is covered by one or more claims of patents owned by ViaCyte, including WO2005063971, WO2006017134, WO2006071911, WO2005116073 and WO2006016999, and their foreign counterparts. The use of the deliverables is strictly limited to purchaser's own internal research. Purchaser has no right to use the deliverables or their components in humans for any purposes including but not limited to diagnostics, therapeutics, or clinical trials. Purchaser has no right to resell or transfer the deliverables to a third party regardless of whether or not compensation is received. Purchasers wishing to use the deliverables for purposes other than internal research use should contact Takara. No express or implied license is granted to the purchaser.
C015 This service is performed by Takara Bio Europe AB based on a commercial license to certain intellectual property rights held by Wisconsin Alumni Research Foundation (“WARF”). The deliverables and their use are covered by one or more claims of U.S. Patent No. 7,514,260 and its foreign counterparts. The purchase of this service conveys to the buyer the non-transferable right to use the deliverables for their intended use, strictly limited to purchaser’s own internal research. No other express or implied license is granted to the purchaser. Purchaser cannot have any right to use the deliverables or its components in humans for any purposes including but not limited to diagnostics and/or therapeutics, or otherwise clinical trials. Purchase does not include any right to resell or transfer the deliverables to a third party regardless of whether or not compensation is received. Purchasers wishing to use the deliverables for purposes other than internal research use should contact us.
*

With Cellartis directed differentiation services, we will deliver high-quality, custom hepatocytes or definitive endoderm cells derived from your human ES or iPS cells.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Y60212 Cellartis® hiPS Directed Differentiation to DE Cells Service (5 vials) Each Inquire for Quotation

License Statement

ID Number  
C013 This service is performed by Takara Bio Inc. and/or its affiliate(s) (“Takara”) under a license from ViaCyte Inc. (“ViaCyte”). This product is covered by one or more claims of patents owned by ViaCyte, including WO2005063971, WO2006017134, WO2006071911, WO2005116073 and WO2006016999, and their foreign counterparts. The use of the deliverables is strictly limited to purchaser's own internal research. Purchaser has no right to use the deliverables or their components in humans for any purposes including but not limited to diagnostics, therapeutics, or clinical trials. Purchaser has no right to resell or transfer the deliverables to a third party regardless of whether or not compensation is received. Purchasers wishing to use the deliverables for purposes other than internal research use should contact Takara. No express or implied license is granted to the purchaser.
L69 This product is covered by one or more claims of the issued patents and pending patent applications: U.S. Patent Nos. 8,048,999, 8,058,065, 8,129,187, 8,211,697, 8,257,941, 8,278,104, 8,530,238, 8,900,871, 8,927,277, 8,951,801, 9,213,999, 9,404,124, 9,499,797, 9,677,141, 9,714,433, and 9,938,585 and foreign counterparts thereof, including their divisions, continuations, extensions, substitutions, and those claiming priority therefrom or those claiming the same priorities therein.

This custom service is provided by Takara Bio Inc. and/or its affiliate(s) based on a patent license from iPS Academia Japan, Inc. No express or implied license is granted to the purchaser. "Product" means the customized differentiated cells manufactured and sold by Takara Bio Inc.

"Internal research purpose" means the use of this Product as a tool of internal research for the sole benefit of the purchaser or purchaser's contract research customer, (including screening of compounds, antibodies, proteins, peptides and others in developing pharmaceuticals (including diagnostic agents) for human and/or animal use), provided, however, that the following activities using this Product are strictly prohibited and expressly excluded from Internal research purposes:

With the exemption for academic and non-commercial clinical research done by non-profit institutions;

1) Administration of this Product to humans.

2) Use of this Product for the diagnostic testing, prevention, or treatment of human and/or animal diseases.

3) Use of this Product in studies involving administration to humans for cell therapy, regenerative medicine etc.

Purchaser may use this Product for its own Internal research purposes.

Purchaser shall not use the Products for its commercial purposes.

Notwithstanding the foregoing, the purchaser of this Product may provide third parties with contract research services by using this Product only for such third party's Internal research purposes.
*

With the Cellartis hiPS directed differentiation to DE cells service, we will deliver high-quality, custom definitive endoderm cells derived from your human iPS cells.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Y60213 Cellartis® hES Directed Differentiation to DE Cells Service (5 vials) Each Inquire for Quotation

License Statement

ID Number  
C015 This service is performed by Takara Bio Europe AB based on a commercial license to certain intellectual property rights held by Wisconsin Alumni Research Foundation (“WARF”). The deliverables and their use are covered by one or more claims of U.S. Patent No. 7,514,260 and its foreign counterparts. The purchase of this service conveys to the buyer the non-transferable right to use the deliverables for their intended use, strictly limited to purchaser’s own internal research. No other express or implied license is granted to the purchaser. Purchaser cannot have any right to use the deliverables or its components in humans for any purposes including but not limited to diagnostics and/or therapeutics, or otherwise clinical trials. Purchase does not include any right to resell or transfer the deliverables to a third party regardless of whether or not compensation is received. Purchasers wishing to use the deliverables for purposes other than internal research use should contact us.
C013 This service is performed by Takara Bio Inc. and/or its affiliate(s) (“Takara”) under a license from ViaCyte Inc. (“ViaCyte”). This product is covered by one or more claims of patents owned by ViaCyte, including WO2005063971, WO2006017134, WO2006071911, WO2005116073 and WO2006016999, and their foreign counterparts. The use of the deliverables is strictly limited to purchaser's own internal research. Purchaser has no right to use the deliverables or their components in humans for any purposes including but not limited to diagnostics, therapeutics, or clinical trials. Purchaser has no right to resell or transfer the deliverables to a third party regardless of whether or not compensation is received. Purchasers wishing to use the deliverables for purposes other than internal research use should contact Takara. No express or implied license is granted to the purchaser.
*

With the Cellartis hES directed differentiation to DE cells service, we will deliver high-quality, custom definitive endoderm cells derived from your human ES cells.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Y60214 Cellartis® hiPS Directed Differentiation to DE Cells Service (Add-On, 30 vials) Each Inquire for Quotation

License Statement

ID Number  
C013 This service is performed by Takara Bio Inc. and/or its affiliate(s) (“Takara”) under a license from ViaCyte Inc. (“ViaCyte”). This product is covered by one or more claims of patents owned by ViaCyte, including WO2005063971, WO2006017134, WO2006071911, WO2005116073 and WO2006016999, and their foreign counterparts. The use of the deliverables is strictly limited to purchaser's own internal research. Purchaser has no right to use the deliverables or their components in humans for any purposes including but not limited to diagnostics, therapeutics, or clinical trials. Purchaser has no right to resell or transfer the deliverables to a third party regardless of whether or not compensation is received. Purchasers wishing to use the deliverables for purposes other than internal research use should contact Takara. No express or implied license is granted to the purchaser.
L69 This product is covered by one or more claims of the issued patents and pending patent applications: U.S. Patent Nos. 8,048,999, 8,058,065, 8,129,187, 8,211,697, 8,257,941, 8,278,104, 8,530,238, 8,900,871, 8,927,277, 8,951,801, 9,213,999, 9,404,124, 9,499,797, 9,677,141, 9,714,433, and 9,938,585 and foreign counterparts thereof, including their divisions, continuations, extensions, substitutions, and those claiming priority therefrom or those claiming the same priorities therein.

This custom service is provided by Takara Bio Inc. and/or its affiliate(s) based on a patent license from iPS Academia Japan, Inc. No express or implied license is granted to the purchaser. "Product" means the customized differentiated cells manufactured and sold by Takara Bio Inc.

"Internal research purpose" means the use of this Product as a tool of internal research for the sole benefit of the purchaser or purchaser's contract research customer, (including screening of compounds, antibodies, proteins, peptides and others in developing pharmaceuticals (including diagnostic agents) for human and/or animal use), provided, however, that the following activities using this Product are strictly prohibited and expressly excluded from Internal research purposes:

With the exemption for academic and non-commercial clinical research done by non-profit institutions;

1) Administration of this Product to humans.

2) Use of this Product for the diagnostic testing, prevention, or treatment of human and/or animal diseases.

3) Use of this Product in studies involving administration to humans for cell therapy, regenerative medicine etc.

Purchaser may use this Product for its own Internal research purposes.

Purchaser shall not use the Products for its commercial purposes.

Notwithstanding the foregoing, the purchaser of this Product may provide third parties with contract research services by using this Product only for such third party's Internal research purposes.
*

With the Cellartis hiPS directed differentiation to DE cells service, we will deliver high-quality, custom definitive endoderm cells derived from your human iPS cells.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Y60215 Cellartis® hES Directed Differentiation to DE Cells Service (Add-On, 30 vials) Each Inquire for Quotation

License Statement

ID Number  
C015 This service is performed by Takara Bio Europe AB based on a commercial license to certain intellectual property rights held by Wisconsin Alumni Research Foundation (“WARF”). The deliverables and their use are covered by one or more claims of U.S. Patent No. 7,514,260 and its foreign counterparts. The purchase of this service conveys to the buyer the non-transferable right to use the deliverables for their intended use, strictly limited to purchaser’s own internal research. No other express or implied license is granted to the purchaser. Purchaser cannot have any right to use the deliverables or its components in humans for any purposes including but not limited to diagnostics and/or therapeutics, or otherwise clinical trials. Purchase does not include any right to resell or transfer the deliverables to a third party regardless of whether or not compensation is received. Purchasers wishing to use the deliverables for purposes other than internal research use should contact us.
C013 This service is performed by Takara Bio Inc. and/or its affiliate(s) (“Takara”) under a license from ViaCyte Inc. (“ViaCyte”). This product is covered by one or more claims of patents owned by ViaCyte, including WO2005063971, WO2006017134, WO2006071911, WO2005116073 and WO2006016999, and their foreign counterparts. The use of the deliverables is strictly limited to purchaser's own internal research. Purchaser has no right to use the deliverables or their components in humans for any purposes including but not limited to diagnostics, therapeutics, or clinical trials. Purchaser has no right to resell or transfer the deliverables to a third party regardless of whether or not compensation is received. Purchasers wishing to use the deliverables for purposes other than internal research use should contact Takara. No express or implied license is granted to the purchaser.
*

With the Cellartis hES directed differentiation to DE cells service, we will deliver high-quality, custom definitive endoderm cells derived from your human ES cells.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Y60301 Cellartis® Human Pathogen and Mycoplasma Testing Service Each USD $1485.00

With Cellartis directed differentiation services, we will deliver high-quality, custom hepatocytes or definitive endoderm cells derived from your human ES or iPS cells.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Y60302 Cellartis® Sterility Testing Service Each USD $711.00

With Cellartis directed differentiation services, we will deliver high-quality, custom hepatocytes or definitive endoderm cells derived from your human ES or iPS cells.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.


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Takara Bio USA, Inc. provides kits, reagents, instruments, and services that help researchers explore questions about gene discovery, regulation, and function. As a member of the Takara Bio Group, Takara Bio USA is part of a company that holds a leadership position in the global market and is committed to improving the human condition through biotechnology. Our mission is to develop high-quality innovative tools and services to accelerate discovery.

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