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Showing 1-10 of 19 results

iDimerize™ Reverse Dimerization System

Cat. # Product Size License Quantity Details
635066 iDimerize™ Reverse Dimerization System Each USD $1095.00

The iDimerize Reverse Dimerization System lets you control the subcellular localization, catalytic activity, and secretion of a protein of interest in live cells via a membrane-permeant compound. The system includes the iDimerize Reverse Dimerization Vector Set 1, which contains three mammalian expression vectors encoding fusion tags (i.e., self-assembly domains in combination with different localization sequences) that can be easily added to your protein of interest. The aggregation state of the resulting chimeric protein can be controlled by the addition of a small molecule to the cell medium. In the absence of the compound, the tagged protein expressed by the system self-assembles into complexes; when the compound is added to the cell medium, the complexes disaggregate, allowing the now soluble tagged proteins to regain their normal function. The system also includes a membrane-permeant, solubilizing compound, D/D Solubilizer, required for dissolving aggregates, and two linear selection markers for hygromycin and puromycin resistance.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

iDimerize™ Inducible Homodimer System

Cat. # Product Size License Quantity Details
635068 iDimerize™ Inducible Homodimer System Each USD $1095.00

The iDimerize Inducible Homodimer System lets you control the homodimerization of a protein of interest in live cells via a membrane permeant compound. The system includes the iDimerize Inducible Homodimer Vector Set 1, which contains two mammalian expression vectors encoding fusion tags that can be easily added to your protein of interest. The activity and localization of the resulting chimeric protein can be controlled by the addition of a small molecule to the cell medium. The system also includes the membrane-permeant compound, B/B Homodimerizer, required for homodimerization, and two linear selection markers for hygromycin and puromycin resistance.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

iDimerize™ Inducible Homodimer System (with Tet-On® 3G)

Cat. # Product Size License Quantity Details
635084 iDimerize™ Inducible Homodimer System (with Tet-On® 3G) Each USD $1195.00

The iDimerize Inducible Homodimer System (with Tet-On 3G) lets you control the expression level and dimerization of a protein of interest in live cells. The system includes the iDimerize Inducible Homodimer Vector Set 2, which contains a mammalian expression vector (pTRE3G-Hom1) that allows doxycycline-dependent expression of your protein of interest, tagged with the DmrB domain, in Tet-On 3G transactivator-expressing cells. Homodimerization of the resulting DmrB-tagged protein is controlled by the addition of the B/B Homoodimerizer.

The iDimerize Inducible Homodimer System (with Tet-On 3G) includes vectors and linear selection markers, our highly efficient transfection reagent, Xfect, Tet System Approved FBS, and the B/B Homodimerizer.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Lenti-X™ iDimerize™ Inducible Heterodimer System

Cat. # Product Size License Quantity Details
635074 Lenti-X™ iDimerize™ Inducible Heterodimer System Each USD $1195.00

The Lenti-X iDimerize Inducible Heterodimer System lets you control the heterodimerization of two different proteins of interest in live cells by adding a small molecule, the membrane-permeant compound A/C Heterodimerizer, to the culture medium. The system includes the Lenti-X iDimerize Inducible Heterodimer Vector Set 1, which contains four lentiviral vectors encoding dimerization tags (DmrA or DmrC, respectively), as well as subcellular localization tags that can be easily fused to your protein of interest. In combination with a lentiviral packaging system, the optimized Lenti-X constructs allow for packaging and delivery of high-titer lentivirus to the widest range of cell types. Using this system, the activity and/or localization of the resulting chimeric protein can be controlled by the addition of A/C Heterodimerizer, which is required for heterodimerization and is also included.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Required Products

Cat. # Product Size Price License Quantity Details
632180 Lenti-X™ 293T Cell Line 1 mL USD $361.00

The Lenti-X 293T Cell Line is a subclone of the transformed human embryonic kidney cell line, HEK 293, which is highly transfectable and supports high levels of viral protein expression. When transfected with Lenti-X Packaging Single Shots and a lentiviral vector, these cells are capable of producing lentiviral titers as high as >108 ifu/ml, as determined by flow cytometry. The cell line also constitutively expresses the simian virus 40 (SV40) large T antigen.

631275 Lenti-X™ Packaging Single Shots (VSV-G) 16 Rxns USD $919.00

Lenti-X Packaging Single Shots (VSV-G) provide an extremely simple and consistent one-step method for producing high-titer lentivirus. No additional transfection reagent is needed because Lenti-X Packaging Single Shots (VSV-G) consist of pre-aliquoted, lyophilized, single tubes of Xfect Transfection Reagent premixed with an optimized formulation of VSV-G pseudotyped Lenti-X lentiviral packaging plasmids. High-titer virus is produced by simply reconstituting this mixture with your lentiviral vector of choice in sterile water and adding it to 293T cells, e.g., Lenti-X 293T Cells (Cat. # 632180), in a 10 cm dish.

Lenti-X™ iDimerize™ Inducible Homodimer System

Cat. # Product Size License Quantity Details
635072 Lenti-X™ iDimerize™ Inducible Homodimer System Each USD $1195.00

The Lenti-X iDimerize Inducible Homodimer Vector Set 1 is a component of the Lenti-X iDimerize Inducible Homodimer System (Cat. No. 635072). This system enables lentiviral delivery of your gene of interest into a variety of mammalian cells, and the expression of your protein of interest, tagged with a domain allowing for inducible protein homodimerization, via a small molecule "dimerizer".

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Lenti-X™ iDimerize™ Inducible Homodimer System (with Tet-On® 3G)

Cat. # Product Size License Quantity Details
635086 Lenti-X™ iDimerize™ Inducible Homodimer System (with Tet-On® 3G) Each USD $1768.00

The Lenti-X iDimerize Inducible Homodimer System (with Tet-On 3G) is a tetracycline-inducible lentiviral gene expression system that lets you control the expression level and dimerization of a protein of interest in live cells. The system includes the pLVX-TRE3G-Hom1 Vector Set, which contains a mammalian expression vector (pLVX-TRE3G-Hom1) that allows doxycycline-dependent expression of your gene of interest, tagged with the DmrB domain, in Tet-On 3G transactivator-expressing cells. Homodimerization of the resulting DmrB-tagged protein is controlled by the addition of the B/B Homodimerizer.

The Lenti-X iDimerize Inducible Homodimer System (with Tet-On 3G) includes vectors and linear selection markers, an optimized packaging system, and the B/B Homodimerizer. The system provides enough reagents for 16 lentiviral packaging reactions.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Lenti-X™ iDimerize™ Reverse Dimerization System

Cat. # Product Size License Quantity Details
635076 Lenti-X™ iDimerize™ Reverse Dimerization System Each USD $1195.00

The Lenti-X iDimerize Reverse Dimerization Vector Set 1 is a component of the Lenti-X iDimerize Reverse Dimer System (Cat. No. 635076). This system enables lentiviral delivery of your gene of interest into a variety of mammalian cells, and the expression of your protein of interest, tagged with a domain allowing for reversible protein dimerization/aggregation, via a small molecule "solubilizer".

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

B/B Washout Ligand

Cat. # Product Size License Quantity Details
635088 B/B Washout Ligand 500 uL USD $352.00

B/B Washout Ligand is a membrane-permeant ligand that dissociates protein interactions induced by the B/B Homodimerizer, which is provided in each of the iDimerize Inducible Homodimer Systems (Cat. Nos. 635068, 635072, 635084, and 635086). The B/B Washout Ligand dissociates these interactions with a T1/2 of ~10 minutes after adding it to target cells treated with B/B Homodimerizer.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

iDimerize™ Inducible Heterodimer System

Cat. # Product Size License Quantity Details
635067 iDimerize™ Inducible Heterodimer System Each USD $1095.00

The iDimerize Inducible Heterodimer System lets you control the heterodimerization of two different proteins of interest in live cells via a membrane-permeant compound. The system includes the iDimerize Inducible Heterodimer Vector Set 1, which contains three mammalian expression vectors encoding fusion tags that can be easily added to your proteins of interest. The activity and localization of the resulting chimeric proteins can be controlled by the addition of a small molecule to the cell medium. The system also includes the membrane-permeant compound, A/C Heterodimerizer, required for heterodimerization, and two linear selection markers for hygromycin and puromycin resistance.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

iDimerize™ Inducible Heterodimer System (with Tet-On® 3G)

Cat. # Product Size License Quantity Details
635079 iDimerize™ Inducible Heterodimer System (with Tet-On® 3G) Each USD $1195.00

The iDimerize Inducible Heterodimer System (with Tet-On 3G) lets you control the expression levels and heterodimerization of two different proteins of interest, encoded on a single vector, in live cells. The system includes the iDimerize Inducible Heterodimer Vector Set 2, which contains a mammalian bidirectional expression vector (pTRE3G-BI-Het1) that allows simultaneous, doxycycline-dependent expression of two proteins of interest, tagged with the DmrA and DmrC domains, respectively, in Tet-On 3G transactivator-expressing cells. The activity and localization of the resulting DmrA- and DmrC-tagged proteins is controlled by the addition of the A/C Heterodimerizer.

The iDimerize Inducible Heterodimer System (with Tet-On 3G) includes vectors and linear selection markers, our highly efficient transfection reagent, Xfect, Tet System Approved FBS, and the A/C Heterodimerizer.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Showing 1-10 of 19 results