Refine Your Search

Available results will be divided among three tabs below.
Options for narrowing the number of matches are available on the left.

Adding terms to the "Refine Your Search" box will apply more criteria to your current results. Making selections in the "Search Filters" box will further limit your results within a variety of categories, such as application, product type, kit size, etc.

Showing 1-10 of 10 results
 

pAP1(PMA)-TA-Luc Vector

Cat. # Product Size License Quantity Details
631906 pAP1(PMA)-TA-Luc Vector 20 ug USD $453.00

This vector is designed for monitoring the activation of the activation of activator protein 1 (AP1) by phorbol esters (PMA). The AP1(PMA) element responds specifically to PMA treatment for studying activation of the protein kinase C (PKC) pathway. When transfected into mammalian cells, the vector can be used for studying effects of activation of this and related signal transduction pathways. The vector contains the gene encoding firefly luciferase as the reporter, which can be measured by any standard luciferase assay.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

pAP1(PMA)-SEAP Vector

Cat. # Product Size License Quantity Details
631907 pAP1(PMA)-SEAP Vector 20 ug USD $467.00

This vector is designed for monitoring the activation of Activator Protein 1 (AP1) by phorbol esters (PMA). The AP1(PMA) element responds specifically to PMA treatment for studying activation of the protein kinase C (PKC) pathway. When transfected into mammalian cells, the vector can be used for studying effects of activation of this and related signal transduction pathways. The vector contains the gene encoding secreted alkaline phosphatase (SEAP) as the reporter.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Raf Dominant-Negative Vector Set

Cat. # Product Size License Quantity Details
631926 Raf Dominant-Negative Vector Set Each USD $645.00

Set of three vectors for studying Raf or MAPK signaling pathways: the pCMV-Raf-1 Vector expresses the wild-type Raf protein, the pCMV-RafCAAX expresses a constitutively active form of the Raf protein, and the pCMV-RafS621A Vector expresses a mutated form of Ras with a Ser-to-Ala mutation at residue 621. These vectors can be used to study Raf-related signal transduction pathways in mammalian cells. Each gene is expressed from the constitutive CMV promoter.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

pSRE-SEAP Vector

Cat. # Product Size License Quantity Details
631901 pSRE-SEAP Vector 20 ug USD $467.00

pSRE-SEAP is a reporter vector that is ideal for studying the induction of the serum response element (SRE). SRE is induced through the mitogen activated protein (MAP) kinase signal transduction pathway. pSRE-SEAP contains the secreted alkaline phosphatase (SEAP) gene as the reporter. pTAL-SEAP is provided as a negative control to measure background signals, or it can be used for studying putative enhancer elements, which can be cloned into the MCS.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

pAP1-SEAP Vector

Cat. # Product Size License Quantity Details
631903 pAP1-SEAP Vector 20 ug USD $467.00

pAP1-SEAP is a reporter vector that is ideal for studying the induction of the activator protein 1 (AP1). AP1 is induced through the SAPK/JNK signal transduction pathway. pAP1-SEAP contains the secreted alkaline phosphatase (SEAP) gene as the reporter. pTAL-SEAP is provided as a negative control to measure background signals, or it can be used for studying putative enhancer elements, which can be cloned into the MCS.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

p53 Dominant-Negative Vector Set

Cat. # Product Size License Quantity Details
631922 p53 Dominant-Negative Vector Set Each USD $645.00

Set of two vectors for studying p53 and related signaling pathways. pCMV-p53 expresses the wild-type p53 tumor suppressor protein. pCMV-p53mt135 contains the gene encoding a dominant-negative mutation of p53 that blocks normal p53 activity. Both genes are expressed from the constitutive CMV promoter. Use these vectors in mammalian systems for studying p53 function in apoptosis, cell growth, and DNA damage repair.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

IkappaBalpha Dominant-Negative Vector Set

Cat. # Product Size License Quantity Details
631923 IkappaBalpha Dominant-Negative Vector Set Each USD $645.00

Set of two vectors for studying NFκB and related signaling pathways. The pCMV-IκBα Vector expresses the wild-type IκBα protein. The pCMV-IκBαM Vector contains a mutated form of IκBα with a serine-to-alanine mutation at residues 32 and 36. This mutated form does not undergo signal-induced phosphorylation, and thus, remains bound to NFκB. Both genes are expressed from the constitutive CMV promoter.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Ras Dominant-Negative Vector Set

Cat. # Product Size License Quantity Details
631924 Ras Dominant-Negative Vector Set Each USD $645.00

Set of three vectors for studying Ras or MAPK signaling pathways. The pCMV-Ras Vector expresses the wild-type Ha-ras protein. The pCMV-RasN17 Vector contains a mutated form of Ras with a serine-to-asparagine mutation at residue 17. To constitutively express Ras, pCMV-RasV12 contains a mutated form of Ras with a glycine-to-valine mutation at residue 12.
These vectors can be used to study Ras-related signal transduction pathways in mammalian cells. Each gene is expressed from the constitutive CMV promoter.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

CREB Dominant-Negative Vector Set

Cat. # Product Size License Quantity Details
631925 CREB Dominant-Negative Vector Set Each USD $645.00

Set of three vectors for studying CREB-related signaling pathways. The pCMV-CREB Vector expresses the wild-type CREB protein. pCMVCREB133 Vector encodes a mutated form of CREB, blocking cAMP-induced transcription and preventing CREB phosphorylation. pCMVKCREB also encodes a mutated form of CREB, blocking cAMP-induced transcription. Each gene is expressed from the constitutive CMV promoter.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

ApopLadder Ex™

Cat. # Product Size License Quantity Details
MK600 ApopLadder Ex™ 24 Rxns USD $243.00

The ApopLadder Ex Kit selectively extracts the small, fragmented DNA from apoptotic cells and minimizes chromatin contamination. This method supports highly sensitive detection and quantitation of fragmented DNA. Detection of fragmented DNA following isolation can be observed by gel electrophoresis and can be quantitated by fluorescent staining with intercalating green dye. This kit contains the necessary reagents for cell lysis, enzymatic degradation of protein and RNA, precipitation of the DNA fragments, and a 6X loading dye for gel electrophoresis.

Notice to purchaser

Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval.

Showing 1-10 of 10 results