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Cell biology assays [1]

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Cell signaling [1]

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Raf Dominant-Negative Vector Set

Cat. #	Product	Size		License	Quantity	Details
631926	Raf Dominant-Negative Vector Set	Each	USD $645.00
Set of three vectors for studying Raf or MAPK signaling pathways: the pCMV-Raf-1 Vector expresses the wild-type Raf protein, the pCMV-RafCAAX expresses a constitutively active form of the Raf protein, and the pCMV-RafS621A Vector expresses a mutated form of Ras with a Ser-to-Ala mutation at residue 621. These vectors can be used to study Raf-related signal transduction pathways in mammalian cells. Each gene is expressed from the constitutive CMV promoter. Notice to purchaser Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval. Documents Components Image Data Back Signal transduction kits are available for in vivo studies of signal transduction—from signaling cascades to gene transcription *Signal transduction kits are available for in vivo* studies of signal transduction—from signaling cascades to gene transcription. Back Inhibition of NFκB activity using pCMV-IκBα and pCMVκIαBM from the IκB Dominant-Negative Vector Set Inhibition of NFκB activity using pCMV-IκBα and pCMVκIαBM from the IκB Dominant-Negative Vector Set (Cat. # 631923).** HEK 293 cells were transiently transfected with the indicated plasmids. After 16 hr, fresh medium was added to the cells along with TNF to induce the NFκB pathway. SEAP activity was assayed 6 hr later to determine NFκB activity. Back 631926: Raf Dominant-Negative Vector Set