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Cell biology assays [1]

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Cell signaling [1]

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Ras Dominant-Negative Vector Set

Cat. #	Product	Size		License	Quantity	Details
631924	Ras Dominant-Negative Vector Set	Each	USD $645.00
Set of three vectors for studying Ras or MAPK signaling pathways. The pCMV-Ras Vector expresses the wild-type Ha-ras protein. The pCMV-RasN17 Vector contains a mutated form of Ras with a serine-to-asparagine mutation at residue 17. To constitutively express Ras, pCMV-RasV12 contains a mutated form of Ras with a glycine-to-valine mutation at residue 12. These vectors can be used to study Ras-related signal transduction pathways in mammalian cells. Each gene is expressed from the constitutive CMV promoter. Notice to purchaser Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval. Documents Components Image Data Back Signal transduction kits are available for in vivo studies of signal transduction—from signaling cascades to gene transcription *Signal transduction kits are available for in vivo* studies of signal transduction—from signaling cascades to gene transcription. Back Inhibition of NFκB activity using pCMV-IκBα and pCMVκIαBM from the IκB Dominant-Negative Vector Set Inhibition of NFκB activity using pCMV-IκBα and pCMVκIαBM from the IκB Dominant-Negative Vector Set (Cat. # 631923).** HEK 293 cells were transiently transfected with the indicated plasmids. After 16 hr, fresh medium was added to the cells along with TNF to induce the NFκB pathway. SEAP activity was assayed 6 hr later to determine NFκB activity. Back 631924: Ras Dominant-Negative Vector Set