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631923

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Cell biology assays [1]

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Cell signaling [1]

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IkappaBalpha Dominant-Negative Vector Set

Cat. #	Product	Size		License	Quantity	Details
631923	IkappaBalpha Dominant-Negative Vector Set	Each	USD $645.00
Set of two vectors for studying NFκB and related signaling pathways. The pCMV-IκBα Vector expresses the wild-type IκBα protein. The pCMV-IκBαM Vector contains a mutated form of IκBα with a serine-to-alanine mutation at residues 32 and 36. This mutated form does not undergo signal-induced phosphorylation, and thus, remains bound to NFκB. Both genes are expressed from the constitutive CMV promoter. Notice to purchaser Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval. Documents Components Image Data Back Signal transduction kits are available for in vivo studies of signal transduction—from signaling cascades to gene transcription *Signal transduction kits are available for in vivo* studies of signal transduction—from signaling cascades to gene transcription. Back Inhibition of NFκB activity using pCMV-IκBα and pCMVκIαBM from the IκB Dominant-Negative Vector Set Inhibition of NFκB activity using pCMV-IκBα and pCMVκIαBM from the IκB Dominant-Negative Vector Set (Cat. # 631923).** HEK 293 cells were transiently transfected with the indicated plasmids. After 16 hr, fresh medium was added to the cells along with TNF to induce the NFκB pathway. SEAP activity was assayed 6 hr later to determine NFκB activity. Back 631923: IkappaBalpha Dominant-Negative Vector Set