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Cell biology assays [1]

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Cell signaling [1]

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p53 Dominant-Negative Vector Set

Cat. #	Product	Size		License	Quantity	Details
631922	p53 Dominant-Negative Vector Set	Each	USD $645.00
Set of two vectors for studying p53 and related signaling pathways. pCMV-p53 expresses the wild-type p53 tumor suppressor protein. pCMV-p53mt135 contains the gene encoding a dominant-negative mutation of p53 that blocks normal p53 activity. Both genes are expressed from the constitutive CMV promoter. Use these vectors in mammalian systems for studying p53 function in apoptosis, cell growth, and DNA damage repair. Notice to purchaser Our products are to be used for Research Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval. Documents Components Image Data Back Signal transduction kits are available for in vivo studies of signal transduction—from signaling cascades to gene transcription *Signal transduction kits are available for in vivo* studies of signal transduction—from signaling cascades to gene transcription. Back Inhibition of NFκB activity using pCMV-IκBα and pCMVκIαBM from the IκB Dominant-Negative Vector Set Inhibition of NFκB activity using pCMV-IκBα and pCMVκIαBM from the IκB Dominant-Negative Vector Set (Cat. # 631923).** HEK 293 cells were transiently transfected with the indicated plasmids. After 16 hr, fresh medium was added to the cells along with TNF to induce the NFκB pathway. SEAP activity was assayed 6 hr later to determine NFκB activity. Back 631922: p53 Dominant-Negative Vector Set