- Alzheimer's disease
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Anti-human Rheb (R165) rabbit IgG antibody
Ras homolog enriched in brain (Rheb) is a member of the small GTPase superfamily of proteins and is encoded by the RHEB gene in humans. Rheb is a lipid-anchored, cell-membrane protein that contains five repeats of the RAS-related GTP-binding region. It alternates between GDP- and GTP-bound forms; post-translational modification by addition of a farnesyl group is required for this activity. Rheb is an essential component of the insulin/TOR/S6K signaling pathway that regulates cell cycle progression and cell growth. Rheb activates mammalian target of rapamycin (mTOR) kinase within the mTORC1 complex. Rheb is also known as GTP-binding protein Rheb and RHEB2.
This product is an affinity-purified IgG antibody that recognizes human Rheb protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection or immunoprecipitation (IP) of human Rheb protein.
- Cat.#: 28015A, 28015B
- Target Name: Human Rheb protein
- Antigen: Human Rheb C-terminal synthetic peptide
- Application: WB, IP
- Target Entrez Gene ID: 6009
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Western blot: 0.5-5.0 µg/ml
- Immunoprecipitation: 1-5 µg/ml
Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
GTP-binding protein Rheb, RHEB2
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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