Anti-human XIAP rabbit IgG antibody
Human X-linked inhibitor of apoptosis (XIAP) protein belongs to a family of apoptotic suppressor proteins that share a conserved motif, the baculovirus IAP repeat (BIR). The BIR motif is necessary for antiapoptotic function. XIAP plays a variety of other functional roles, such as modulation of inflammatory signaling and immunity, mitogenic kinase signaling, cell proliferation, and copper homeostasis. XIAP acts as a caspase inhibitor by binding to the active site of caspase 3 and 7; it also inactivates caspase 9 by preventing it from forming active homodimers. Mutations in the XIAP gene are associated with X-linked lymphoproliferative syndrome.
XIAP is also known as baculoviral IAP repeat-containing 4 (BIRC4), inhibitor of apoptosis protein 3 (IAP3), hIAP3, IAP-like protein, API3, ILP1, MIHA, and XLP2.
This product is an affinity-purified IgG antibody that recognizes human XIAP protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection of human XIAP protein.
- Target name: Human XIAP protein
- Antigen: Human XIAP synthetic peptide
- Specificity: Cross-reacts with mouse XIAP
- Application: WB
- Target Entrez Gene ID: 331
- Recommended antibody concentration (the optimal concentration should be determined empirically) for Western blot: 0.1–0.5 µg/ml
- Lyophilized: stable 5 years at 2–8°C.
- In solution: stable 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 50 µg/ml).
X-linked inhibitor of apoptosis, baculoviral IAP repeat-containing 4, BIRC4, inhibitor of apoptosis protein 3, IAP3, hIAP3, IAP-like protein, API3, ILP1, MIHA, XLP2
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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