Anti-human Rad51 (1B1) mouse IgG monoclonal antibody
Members of the Rad51 protein family are highly homologous to bacterial RecA and Saccharomyces cerevisiae Rad51. These proteins are involved in the homologous recombination and repair of double-stranded breaks in DNA. Rad51 can interact with the ssDNA-binding protein RPA and Rad52. Rad51 also interacts with products of two genes implicated in susceptibility to breast cancer, BRCA1 and BRCA2. In particular, BRCA2 protein is shown to regulate both the intracellular localization and DNA-binding ability of Rad51. Inactivation of BRCA2 leads to loss of Rad51-mediated transcriptional control, and this inactivation may be central to genomic instability and tumorigenesis. Rad51 is also known as RAD51 homolog (S. cerevisiae); RAD51 homolog (RecA homolog, E. coli); BRCA1/BRCA2-containing complex, subunit 5; RECA, BRCC5, MRMV2, HRAD51, RAD51A, HsRad51, and HsT16930.
This product is an affinity-purified IgG antibody that recognizes human Rad51 protein. The antibody was raised in mouse using recombinant human Rad51 protein and can be used for Western blot (WB) detection of human Rad51 protein.
- Cat.#: 10161A
- Target Name: Human Rad51 protein
- Antigen: Human Rad51 recombinant protein
- Application: WB
- Target Entrez Gene ID: 5888
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Western blot: 1 µg/ml
Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3.To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
RAD51 homolog (S. cerevisiae); RAD51 homolog (RecA homolog, E. coli); BRCA1/BRCA2-containing complex, subunit 5; RECA, BRCC5, MRMV2, HRAD51, RAD51A, HsRad51, HsT16930
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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