Anti-human LGP2 rabbit IgG antibody
The putative ATP-dependent RNA helicase LGP2 is encoded by the DHX58 gene in humans. LGP2 is also known as DEXH (Asp-Glu-X-His) box polypeptide 58; probable ATP-dependent RNA helicase DHX58, DHX58, protein D11Lgp2 homolog, RIG-I-like receptor LGP2, RLR, RLR3, D11LGP2, and D11LGP2E. LGP2 was first identified in mammary tissue, but its function was subsequently found to be more relevant in innate antiviral immunity. It is essential for producing effective antiviral responses against many viruses that are recognized by the receptors DDX58/RIG-I and IFIH1/MDA5. This role of LGP2, which can have both positive and negative regulatory effects, is complex and depends on the characteristics of the infecting virus and the target cells. It is suggested that its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA, thereby facilitating their recognition by viral receptors. LGP2 binds to ds RNA with high affinity, but it can also bind ss RNA.
This product is an affinity-purified IgG antibody that recognizes human LGP2 protein. The antibody was raised in rabbit using a synthetic peptide. It can be used for Western blot (WB) detection of human LGP2 protein.
- Cat.#: 29030A, 29030B
- Target Name: Human LGP2
- Antigen: Human LGP2 C-terminal synthetic peptide
- Specificity: Reacts with human and mouse LGP2
- Application: WB
- Target Entrez Gene ID: 79132
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Western blot: 1–5 µg/ml
Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
DEXH (Asp-Glu-X-His) box polypeptide 58; probable ATP-dependent RNA helicase DHX58, DHX58, protein D11Lgp2 homolog, RIG-I-like receptor LGP2, RLR, RLR3, D11LGP2, D11LGP2E
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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