Anti-human Langerhans cells mouse monoclonal antibody
Langerhans cells (LC) are dendritic or antigen-presenting cells in the skin and mucous membranes, and contain large structures called Birbeck granules. They are also found in lymph nodes. They express immune response gene-associated antigens on their cell membranes. Langerhans cells in tissue actively capture, uptake, and process antigens. In secondary lymphoid tissue, LCs lose these properties while gaining the ability to interact with naive T-cells. The disease Langerhans cell histiocytosis (LCH) is caused by excess production of LCs. Langerhans cells are also implicated as early targets in HIV infection.
This product is an affinity-purified IgG antibody that recognizes human LCs. It reacts mainly with a protein found in Birbeck granules. The antibody was raised in mouse and can be used for immunohistochemical (IHC) detection of LCs.
- Cat.#: 10101A, 10101B
- Target Name: Human Langerhans cells
- Antigen: Human Langerhans cells
- Application: IHC
- Specificity: Reacts with membrane proteins in Birbeck granules
- Target Entrez Gene ID: n/a
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Immunohistochemical techniques: 1–5 µg/ml
Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration, 100 µg/ml).
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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