Anti-human hnRNP B1 rabbit IgG antibody
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are complexes of RNA and protein in the nucleus that are involved in gene transcription and subsequent post-transcriptional modification of the newly synthesized RNA (pre-mRNA). After RNA splicing, hnRNPs remain bound to spliced introns and target them for subsequent degradation. hnRNPs also play a role in transporting mature mRNAs out of the nucleus. Over 30 hnRNPs are known in humans. hnRNP B1, also called hnRNP A2/B1, is encoded by the HNRPA2B1 gene, and belongs to the A/B subfamily of ubiquitously expressed hnRNPs. Alternative splicing results in two transcript variants that encode different isoforms. hnRNP A2/B1 has been shown to interact with casein kinase 2-alpha-1. Studies in mice suggest that hnRNP A2/B1 may regulate several tumor suppressors and oncogenes in glioblastomas. hnRNP B1 is also known as hnRNP A2/B1, hnRNP A2B1, hnRNP A2, RNPA2, HNRPA2, HNRPB1, SNRPB1, HNRNPA2, HNRNPB1, and HNRPA2B1.
This product is an affinity-purified IgG antibody that recognizes human hnRNP A2/B1 protein. The antibody was raised in rabbit using a synthetic petide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human hnRNP A2/B1 protein.
- Cat.#: 18941A, 18941B
- Target Name: Human hnRNP A2/B1
- Antigen: Human hnRNP A2/B1 N-terminal synthetic peptide
- Application: WB, IHC
- Target Entrez Gene ID: 3181
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Western blot: 0.5 µg/ml
- Immunoprecipitation: 0.5-1.0 µg/ml
Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
hnRNP A2/B1, hnRNP A2B1, hnRNP A2, RNPA2, HNRPA2, HNRPB1, SNRPB1, HNRNPA2, HNRNPB1, HNRPA2B1
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
Takara Bio USA, Inc.
United States/Canada: +1.800.662.2566 • Asia Pacific: +1.650.919.7300 • Europe: +33.(0)1.3904.6880 • Japan: +81.(0)77.565.6999
FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. © 2018 Takara Bio Inc. All Rights Reserved. All trademarks are the property of Takara Bio Inc. or its affiliate(s) in the U.S. and/or other countries or their respective owners. Certain trademarks may not be registered in all jurisdictions. Additional product, intellectual property, and restricted use information is available at takarabio.com.