Anti-human FHIT (F130) rabbit IgG antibody
The human fragile histidine triad (FHIT) gene encodes a protein that is involved in purine metabolism. Aberrant transcripts from this gene, typically from carcinogen-induced damage and translocations, have been found in about half of all esophageal, stomach, and colon carcinomas. Although the exact function of human FHIT protein is not known, animal studies have demonstrated its role as a tumor suppressor in breast and lung cancers. FHIT protein is also known as bis(5'-adenosyl)-triphosphatase, diadenosine 5',5'''-P1,P3-triphosphate hydrolase, AP3A hydrolase, AP3Aase, dinucleosidetriphosphatase, and FRA3B.
This product is an affinity-purified IgG antibody that recognizes human FHIT protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human FHIT protein.
- Cat. # 18163A/B
- Target Name: Human FHIT protein
- Antigen: Human FHIT C-terminal synthetic peptide
- Application: WB, IHC
- Target Entrez Gene ID: 2272
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Western blot: 5 µg/ml
- Immunohistochemical techniques: 2–5 µg/ml
Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
bis(5'-adenosyl)-triphosphatase, diadenosine 5',5'''-P1,P3-triphosphate hydrolase, AP3A hydrolase, AP3Aase, dinucleosidetriphosphatase, FRA3B
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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