Anti-mouse BEC12 (LA5) rat IgG monoclonal antibody
Vascular endothelial cells line the entire circulatory system, and are composed of many distinct types with unique functions. Lymph endothelial cells (LECs) and blood endothelial cells (BECs) have been the subject of intensive study; both types of cells express a similar set of markers, such as CD31, CD34, podocalyxin, and von Willebrand factor (vWF). It has been difficult to distinguish between LECs and BECs in the past. This antibody reacts especially with the arterial microcirculating system, including small arteries and blood capillaries, and also reacts with some small venous endothelial cells. It does not react with LECs.
This product is an affinity-purified IgG antibody that recognizes mouse BECs. The antibody was raised in rat, and can be used for immunohistochemical (IHC) detection of mouse BECs.
- Cat.#: 10363A, 10363B
- Target Name: Mouse BECs
- Antigen: Mouse lymphangioma
- Application: IHC
- Specificity: Reacts with 12 kDa antigen on mouse vascular endothelial membrane. Does not cross-react with endothelial cells of lymph vessels or large- to medium-sized arteries and veins, but cross-reacts with some lymphatic cells. Does not cross-react with human, rat, or guinea pig BECs.
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Immunohistochemical techniques: 0.1–1.0 µg/ml
Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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