Anti-mouse ALK (mAb 16-39) rat IgG antibody
Anaplastic lymphoma kinase (ALK) is a receptor type tyrosine kinase that belongs to the insulin receptor superfamily. It is also known as anaplastic lymphoma receptor tyrosine kinase, Tcrz, CD246, and NBLST3. ALK is expressed in the central and peripheral nervous system at late embryonic stage, and plays an important role in brain development. The ALK gene is rearranged, mutated, or amplified in various tumors, including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. This monoclonal antibody (clone mAb16-39) elicits tyrosine phosphorylation of ALK in human neuroblastoma (SK-N-SH) cells. It also induces further phosphorylation of signal transfer molecules like insulin receptor substrate-1 (IRD-1).
This product is an affinity-purified IgG antibody that recognizes mouse ALK protein. The antibody was raised in rat using a recombinant protein, and can be used for Western blot (WB) detection or immunoprecipitation (IP) of mouse ALK protein.
- Cat. #: 10373B
- Target Name: Mouse ALK protein
- Antigen: Recombinant mouse ALK protein (extracellular domain)
- Application: WB, IP
- Specificity: Cross-reacts with human ALK
- Target Entrez Gene ID: 11682
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Western blot: 1–5 µg/ml
Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
Anaplastic lymphoma receptor tyrosine kinase, Tcrz, CD246, NBLST3
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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