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Polyclonal antibody for TSC1/hamartin detection
The tuberous sclerosis 1 (TSC1) gene in humans encodes a peripheral membrane protein also known as hamartin, TSC, LAM, and KIAA0243. TSC1 complexes with TSC2 (tuberin) and stabilizes it. The TSC1/TSC2 complex inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 (EIF4BP1) and ribosomal protein S6 kinase (S6K1), by negatively regulating signaling in the mammalian target of rapamycin complex 1 (mTORC1). Mutations in the TSC1 gene are associated with the development of tuberous sclerosis.
This product is an affinity-purified IgG antibody that recognizes human TSC1 protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human TSC1 protein.
- Target Name: Human TSC1 protein
- Antigen: Human TSC1 synthetic peptide
- Specificity: Cross-reacts with mouse TSC1
- Target Entrez Gene ID: 7248
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Western blot: 1–5 µg/ml
- Immunohistochemical techniques: 1–5 µg/ml
Lyophilized: stable for 5 years at 2–8°C. In solution: stable for 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
Hamartin, TSC, LAM, KIAA0243
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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