- Alzheimer's disease
- Bone research
- Brain and CNS
Cancer and inflammation
- Bcl-1 cyclin D1
- COX-1 COX-2
- Fatty acid synthase
- Hepatocyte growth factor
- Intelectin-1 Omentin-1
- Napsin A
- Poly ADP-ribose
- Stem cell factor
- Cell adhesion and ECM
- Environmental hazards
- Epigenetic antibodies
- Metabolic diseases
- mTOR signaling
- Signal transduction
- Stem cell research antibodies
- Virus research
- Miscellaneous research areas
The endothelial tyrosine kinase TEK is a cell-surface receptor that binds the growth factor angiopoietin-1. It is closely related to the TIE receptor tyrosine kinase. TEK-mediated signaling regulates angiogenesis, reorganization of the actin cytoskeleton, and survival, proliferation, migration, adhesion, and spreading of endothelial cells. Activation of TEK leads to downstream activation of MAPK1/ERK2 and MAPK3/ERK1 kinases. Mutations in the TEK gene are associated with inherited venous malformations.
This product is an affinity-purified IgG antibody that recognizes TEK/TIE-2 protein. The antibody was raised in mouse using recombinant TEK/TIE-2 protein and can be used for Western blot (WB) detection, immunocytochemical (ICC) detection, immunoprecipitation (IP), or flow cytometry (FCM) of human TEK/TIE-2 protein.
- Target Name: Human TEK/TIE-2 protein
- Antigen: Human TEK/TIE-2 (extracellular domain) recombinant protein
- Target Entrez Gene ID: 7010
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Western blot: 1–5 µg/ml
- Immunocytochemical techniques: 5 µg/ml
- Immunoprecipitation: 3–5 µg per reaction
- Flow cytometry: 1–5 µg per 1 x 105 cells
Lyophilized: stable for 5 years at 2–8°C. In solution: stable for 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
TEK tyrosine kinase, endothelial; endothelial tyrosine kinase; Tunica interna endothelial cell kinase; tyrosine kinase with Ig and EGF homology domains-2 (TIE-2); hTIE2; p140 TEK; CD202b; angiopoietin-1 receptor; VMCM; and VMCM1.
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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