Hepatocyte growth factor detection

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

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Cross-section of human thyroid cancer tissue, after IHC staining with Anti-Human HGF-alpha (H55) Rabbit IgG Antibody

Cross-section of human thyroid cancer tissue, after IHC staining with Anti-Human HGF-alpha (H55) Rabbit IgG Antibody.

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

Hepatocyte Growth factor (HGF) was discovered as a mitogen for hepatocytes. HGF was subsequently found to be identical to the scatter factor, which destroys epithelial cell adhesion and promotes cell movement. Some reports have shown that HGF is expressed in normal and malignant mammary epithelium. HGF has also been reported to promote motility and growth of epithelial cells, to induce morphogenesis of epithelial cells, and to promote vascularization. It has been speculated that HGF is involved in the growth and metastasis of cancer cells. The first step in the initiation of HGF action is dependent on its biding to a specific cell surface receptor, the HGF receptor, encoded by the proto-oncogene c-Met. It has been suggested that c-Met mediates both responses, i.e., promotion of growth and motility of HGF. HGF is synthesized as a 728 amino acid polypeptide that is processed to generate the mature growth factor consisting of a disulfide-linked 69-kDa α chain and a 34-kDa β chain.

Hepatocyte growth factor/scatter factor (HGF) is a liver regeneration and growth factor that was isolated and purified from the plasma of people who suffer from fulminant hepatitis. In addition blood and tissue concentrations being assessed during liver injury, increases in concentration in body fluids have been reported in other types of disease besides liver disease (e.g., inflammatory diseases, neoplastic diseases, and fibrosis). HGF is secreted as an inactive single-chain pro-form, and it exerts its physiological activity after processing by HGF activator (HGFA), coagulation factor VIIa, etc., and conversion to activated HGF, a heterodimer. This product is a kit that measures human HGF by the WHO standard.

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A typical standard curve obtained using the Human Total HGF ELISA Kit

A typical standard curve obtained using the Human Total HGF ELISA Kit.