- Alzheimer's disease
- Bone research
- Brain and CNS
Cancer and inflammation
- Bcl-1 cyclin D1
- COX-1 COX-2
- Fatty acid synthase
- Hepatocyte growth factor
- Intelectin-1 Omentin-1
- Napsin A
- Poly ADP-ribose
- Stem cell factor
- Cell adhesion and ECM
- Environmental hazards
- Epigenetic antibodies
- Metabolic diseases
- mTOR signaling
- Signal transduction
- Stem cell research antibodies
- Virus research
- Miscellaneous research areas
Extracellular-signal-regulated kinase (ERK) detection
Extracellular-signal-regulated kinases (ERKs), also called mitogen-activated protein kinases (MAPKs), are widely expressed signaling proteins that regulate meiosis, mitosis, and postmitotic functions in differentiated cells. Following activation by upstream kinases, ERKs are translocated to the nucleus, where they perform their regulatory functions. Disruption of ERK-mediated pathways is common in many cancers. Two members of this family were originally identified with 85% sequence similarity, called ERK1 and ERK2.
This product is an affinity-purified IgG antibody that recognizes human ERK1 and ERK2 proteins. The antibody was raised in mouse using a recombinant protein, and can be used for Western blot (WB) detection of human ERK1 and ERK2 proteins.
- Target Name: Human ERK1 and ERK2 proteins
- Antigen: Human ERK1 recombinant protein
- Application: WB
- Specificity: Reacts with human ERK1 and ERK2
- Target Entrez Gene ID: 5594, 5595
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Western blot: 1–5 µg/ml
Lyophilized: stable for 5 years at 2–8°C. In solution: stable for 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
ERK1: MAPK3, extracellular signal-regulated kinase 1, insulin-stimulated MAP2 kinase, microtubule-associated protein 2 kinase, PRKM3, ERT2, p44-ERK1, p44-MAPK, HS44KDAP, HUMKER1A, MAP kinase 1, MAPK1. ERK2: MAPK1, extracellular signal-regulated kinase 2, PRKM1, PRKM2, ERT1, p41-ERK1, p41-MAPK, p42-MAPK, MAP kinase 1, MAP kinase 2, MAPK1, MAPK2, p38, p40, p41.
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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