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Polyclonal antibody for Olig2 detection
Oligodendrocyte lineage transcription factor 2 (Olig2) is a basic helix-loop-helix transcription factor expressed in oligodendroglial tumors of the brain. It is also known as protein kinase C binding protein 2 (PRKCBP2), oligodendrocyte transcription factor 2, oligodendrocyte-specific bHLH transcription factor 2, BHLHB1, bHLHe19, OLIGO2, and RACK17. Olig2 protein plays an essential role in regulating the development of oligodendrocytes and motor neurons. Chromosomal translocations in the OLIG2 gene have been associated with T-cell acute lymphoblastic leukemia (T-ALL) and development of Down syndrome. Olig2 expression is useful in distinguishing diffuse gliomas from other types of brain tumors.
This product is an affinity-purified IgG antibody that recognizes human Olig2 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human Olig2 protein.
- Target Name: Human Olig2 protein
- Antigen: Human Olig2 C-terminal synthetic peptide
- Application: WB, IHC
- Specificity: Cross-reacts with mouse and rat Olig2
- Target Entrez Gene ID: 10215
Recommended antibody concentration (the optimal concentration should be determined empirically):
- Western blot: 2 µg/ml
- Immunohistochemical techniques: 0.1–1 µg/ml
Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.
Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 ml H2O (final concentration 100 µg/ml).
Protein kinase C binding protein 2, PRKCBP2, oligodendrocyte transcription factor 2, oligodendrocyte-specific bHLH transcription factor 2, BHLHB1, bHLHe19, OLIGO2, RACK17
Additional product information
Please see the product's Certificate of Analysis for information about storage conditions, product components, and technical specifications. Please see the Kit Components List to determine kit components. Certificates of Analysis and Kit Components Lists are located under the Documents tab.
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