Advancing discovery with a new class of spatial technology—accessible tools for high-resolution insights

Takara Bio R&D scientists work hard every day to expand the capabilities of our revolutionary donation-based, instrument-free spatial technology, often collaborating with outside investigators who are pioneers in their respective fields. We are excited to share our advances at conferences throughout the year, and are eager to make them accessible to all interested researchers.

If you need a flexible, high-definition single-cell mapping solution for unbiased spatial biology discoveries, take inspiration from our scientific poster series testing the limits of Trekker technology:

Seamlessly integrate a straightforward process upstream of your standard single-cell workflow—unlocking true, biologically relevant resolution
No specialized instruments, cell segmentation, or deconvolution required

A scalable, instrument-free approach to true single-cell spatial transcriptomics

We present a truly instrument-free spatial transcriptomics workflow that combines Trekker technology (a barcoded oligonucleotide tagging approach based on the Slide-tags method) with the Illumina single-cell 3’ RNA Prep assay to deliver high-density, high-sensitivity spatial data with true single-cell resolution.

Single-cell boundaries in densely packed tissue are easily resolved without the need for deconvolution or cell segmentation.
Robust detection of low-abundance and spatially restricted transcripts in complex human tissues is enabled with Trekker technology. Clinically relevant genes that are frequently diluted in spot-based methods are clearly resolved in human breast cancer at true single-cell resolution.
Neighborhood-based niche analysis and identification of distinct multicellular microenvironments found in human breast cancer tissue is possible with single-cell spatial resolution.

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