March
March 24, 2022
How do corals go from planktonic larvae to the sedentary polyps we see branching underwater?
Researchers at Tohoku University analyzed this "point of no return" in Acropora tenuis via Hym-248, a metamorphosis-inducing neuropeptide. Read now »
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March 17, 2022
Dr. Shai Izraeli and his team at Schneider Children's Medical Center of Israel found that constitutive activation of interleukin-7 receptor alpha (IL7RA) has the potential to initiate preleukemia in primary human hematopoietic progenitors and cooperates with Cyclin Dependent Kinase Inhibitor 2 A (CDKN2A) silencing in progression into B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Read now »
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March 10, 2022
Researchers from the University of Tokyo used HT-qPCR to characterize the pollution profiles of antimicrobrial resistance genes and mobile gene elements in 24 urban rivers in Tokyo and its surrounding area. River and wastewater samples were categorized based on their HT-qPCR profiles, indicating that this method was useful for characterizing the pollution status in aquatic environments. Read now »
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March 3, 2022
Using distinct models of immunization, researchers from Albert Einstein College of Medicine establish that cognate antigen recognition by CD8+ T cells on dendritic cells initiates their rapid and coordinated production of a burst of CCL3, CCL4, and XCL1 chemokines under the transcriptional control of interferon (IFN) regulatory factor 4 towards CCR2+ Ly6C+ monocytes. Read now »
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February
February 24, 2022
The PI3K/mTOR signaling pathway is a therapeutic target for various types of human tumors, and dual PI3K/mTOR inhibitors demonstrate antitumor activities in both preclinical and clinical studies. However, the molecular mechanisms involved in cellular are not clear in any canine tumors. Read how researchers explored the antitumor activity of gedatolisib—a PI3K/mTOR inhibitor—on cell viability, protein phosphorylation, and cell cycle distribution using 12 canine tumor cell lines from 6 types of tumors. Read now »
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February 17, 2022
Researchers from the University of Wuerzburg, Germany described a step-by-step procedure of isolating native and enzymatically active protein assemblies, such as Vaccinia virus RNA polymerase (vRNAP) complexes. The protocol, adopted from the transient dominant selection (TDS) method, was modified to capture two major vRNAP complexes, which allows the characterization of the marcromolecules in different phases of transcription including initiation, elongation and co-transcriptional capping. Read now »
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February 10, 2022
Interaction of platelet-derived growth factor (PDGF) isoforms with their receptors results in activation and internalization of receptors, with a concomitant activation of downstream signalling pathways. Ubiquitination of PDGFRs serves as a mark to direct the internalization and sorting of the receptors. By overexpressing a panel of deubiquitinating enzymes (DUBs), researchers at the Uppsala University, Sweden found that USP17- and USP4-mediated changes in ubiquitination of PDGFRβ lead to dysregulated signalling and transcription downstream of STAT3, resulting in defects in the control of cell proliferation. Read now »
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February 3, 2022
Researchers at Mirvie developed their own AI to show that cfRNA signatures from a single blood draw can accurately track pregnancy progression independently of clinical factors reliably identify women at risk of developing pre-eclampsia months before presentation of the disease. Read now »
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