July
July 22, 2021
Metagenomic analyses are important throughout the process of microbiome-based product development; however, standardization of these complex methodologies is lacking in this industry. Researchers at the Japan Microbiome Consortium (JMCB) and the National Institute of Advanced Industrial Science and Technology (AIST) used a mock microbiome to compare 11 library prep kits, pinpoint sources of bias, and establish standards for metagenomics of human fecal samples in the microbiome industry. Read now »
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July 15, 2021
Could aberrant DNA methylation cause neuronal differentiation defects in Prader-Willi syndrome (PWS)? In a new study, Soeda et al. examined the ability of PWS patient-derived iPSCs (iPWS) to differentiate into neurons. Whether the iPWS carried a deletion or had methylation defects, they exhibited defective differentiation into ectoderm. The methylation-defective iPWS gave rise to fewer neural stem cells (NSCs), fewer mature neurons, and showed reduced expression of neural stem cell markers, including Pax6. Methylation is proposed to control neural differentiation through regulation of genes in the PWS region on chromosome 15. Read now »
July 8, 2021
Researchers at the Allen Institute For Brain Science used high-sensitivity single-cell RNA-seq to derive a transcriptomic cell-type taxonomy revealing a comprehensive repertoire of glutamatergic and GABAergic neuron types. Read now »
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July 1, 2021
To better understand the CD4/CD8 lineage choice, researchers from the MRC London Institute of Medical Sciences used an scRNA-seq approach to help elucidate patterns of coreceptor gene activity and the associated gene expression. Read now »
