Accelerate drug discovery with high-sensitivity, cost-effective mRNA sequencing

Save 50% on SMART-Seq mRNA 3' DE (192 rxns)

Screening for your next drug candidate?

Conducting high-throughput transcriptomic screens to identify lead compounds can feel like looking for a needle in a vast haystack. With such little margin for error, standard low-sensitivity library preparation—prone to sample dropouts and limited detection of differentially expressed genes—results in missing critical data. For successful drug discovery, every sequencing read counts. You need fast, reliable technology that captures the full transcriptomic landscape on a large scale.

High performance, low cost

SMART-Seq mRNA 3′ DE accelerates drug discovery by enabling direct cell input, enhancing the flexibility and simplifying the complexity of your preparation workflow. Using an end-capture method with unmatched sensitivity and rigorous quality control, this kit ensures confident target identification, minimizes data loss, and avoids costly experimental repeats. With additional options for index-based sample pooling and automation compatibility, SMART-Seq mRNA 3′ DE offers the fastest path to your next drug candidate.

For a limited time, scale up your library preparation at lower cost (~$20 per reaction) by saving 50% on SMART-Seq mRNA 3′ DE (192 rxns) kits. Sign up below to access the discount.

Offer valid in the US and Canada only and expires 4.30.26. No other discounts apply. 

Detect more differentially expressed genes with SMART-Seq library preparation 

SMART-Seq mRNA 3′ DE enabled superior detection of differentially expressed and informative genes compared to the Lexogen kit. Panel A. Boxplots displaying number of expressed genes and informative genes detected when using either a Lexogen library preparation kit (green) or SMART-Seq mRNA 3′ DE from Takara Bio (blue). Each dot represents a sample; black stars represent number of expressed genes in full dataset (left) and number of informative genes (genes with at least ten mapped reads in 50% of the samples) in full dataset (right). **** indicates a p ≤0.0001. Panel B. Venn diagrams showing number of upregulated and downregulated genes detected with the Lexogen Kit (green) or Takara Bio’s SMART-Seq mRNA 3′ DE (blue). Figure adapted from “Optimizing cost-effective gene expression phenotyping approaches in cattle using 3' mRNA sequencing.” (Mohamed et al. 2025, BMC Genomics) under a CC BY 4.0 license.